Test ID: GRP
Cyclic AMP, Urinary Excretion
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
The differential diagnosis of hypercalcemia
An adjunct to serum parathyroid hormone measurements, especially in the diagnosis of parathyroid hormone resistance states, such as pseudohypoparathyroidism
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| CREAS | Creatinine, S | Yes, (order CREAZ) | Yes |
| CAMP | Cyclic Amp, Urinary Excretion | No | Yes |
| CACR | Creatinine, U | Yes, (order RCTUR) | Yes |
Method Name A short description of the method used to perform the test
CREAS/2200, CACR/2151: Enzymatic Colorimetric Assay
CAMO/179: High-Performance Liquid Chromatography (HPLC)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
AMP - ALWAYS ORDER 8771
C AMP - ALWAYS ORDER 8771
Cyclic AMP Excretion - ALWAYS ORDER 8771
Urinary Cyclic AMP - ALWAYS ORDER 8771
Specimen Type Describes the specimen type needed for testing
Urine
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Serum and urine are required. Serum must be drawn at time of urine collection.
Specimen Type: Serum
Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Specimen Volume: 1 mL
Collection Instructions: Label specimen as serum.
Specimen Type: Urine
Container/Tube: 60 mL urine container (Supply T313)
Specimen Volume: 14 mL
Collection Instructions:
1. Collect a random urine specimen.
2. Label specimen as urine.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Urine: 5.5 mL
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | NA |
| Lipemia | NA |
| Icterus | NA |
| Other | NA |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 7 days |
| Frozen | 90 days | |
| Urine | Frozen | 14 days |
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Cyclic AMP functions as an intracellular "second messenger" regulating the activity of intracellular enzymes or proteins in response to a variety of hormones (eg, parathyroid hormone).
Urinary cyclic AMP is elevated in about 85% of patients with hyperparathyroidism.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
1.3-3.7 nmol/dL of glomerular filtrate
Interpretation Provides information to assist in interpretation of the test results
Urinary cyclic AMP is elevated in about 85% of patients with hyperparathyroidism and in about 50% of patients with humoral hypercalcemia of malignancy.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Parathyroid suppression (hypoparathyroidism) does not lower urinary cyclic AMP excretion to definitely subnormal values.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Aurbach GD, Marx SJ, Spiegel AM: Parathyroid hormone, calcitonin, and the calciferols. In Williams Textbook of Endocrinology. Eighth edition. Edited by JD Wilson, DW Foster. Philadelphia, WB Saunders Company, 1992, pp 1413-1415
Method Description Describes how the test is performed and provides a method-specific reference
Adenosine cyclic 3',5'-monophosphate (cyclic AMP) is isolated from the urine by using a standard anion exchange column (Dowex-1 in formate form). An internal standard (8-methylamino cyclic AMP) is used to correct for recovery losses. Once the cyclic AMP has been eluted from the column, it is allowed to react under acidic conditions with chloracetaldehyde to give a flourescent 1, N(6)-ethano derivative of cyclic AMP. The modified nucleotides are excited at 316 nm and the emission is measured at 410 nm in a fluorometric detector. Quantitation is by peak height measurement against a calibration standard. Urine and serum creatinine levels are used to determine the clearance of cyclic AMP from the kidneys. (Aurbach GD, Marx SJ, Spiegel AM: Parathyroid hormone, calcitonin, and the calciferols. In Williams Textbook of Endocrinology. 8th edition. Edited by JD Wilson, DW Foster. Philadelphia, WB Saunders Company, 1992, pp 1413-1415)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Wednesday; 9 a.m.
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
82030
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| CACR | Creatinine, U | 20624-3 |
| 179 | Cyclic Amp, Urinary Excretion | 25498-7 |
| CREAS | Creatinine, S | 2160-0 |
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