Test ID: COHBB
Carbon Monoxide, Blood
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Verifying carbon monoxide toxicity in cases of suspected exposure
Method Name A short description of the method used to perform the test
Carboxyhemoglobin-Co-oximetry
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
CO (Carbon Monoxide)
Carbon Monoxide (Carboxyhemoglobin)
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Container/Tube: Lavender top (EDTA)
Specimen Volume: 1 mL
Collection Instructions: Avoid exposure of specimen to atmosphere.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | Mild OK; Gross OK |
| Lipemia | Mild OK; Gross OK |
| Icterus | Mild OK; Gross OK |
| Other | NA |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| Whole Blood EDTA | Ambient (preferred) | 14 days |
| Frozen | 14 days | |
| Refrigerated | 14 days |
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Carbon monoxide (CO) poisoning causes anoxia, because CO binds to hemoglobin with an affinity 240 times greater than that of oxygen, thus preventing delivery of oxygen to the tissues. Twenty percent saturation of hemoglobin induces symptoms (headache, fatigue, dizziness, confusion, nausea, vomiting, increased pulse, and respiratory rate). Sixty percent saturation is usually fatal. This concentration is reached when there is 1 part CO per 1,000 parts air.
Carboxyhemoglobin diminishes at a rate of about 15% per hour when the patient is removed from the contaminated environment.
The most common cause of CO toxicity is exposure to automobile exhaust fumes. Significant levels of carboxyhemoglobin can also be observed in heavy smokers. Victims of fires often show elevated levels from inhaling CO generated during combustion. Susceptibility to CO poisoning is increased in anemic persons.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Normal: <7%
1% (lower limit of detectability)
<15% (heavy smoker)
Toxic concentration: > or =20%
Interpretation Provides information to assist in interpretation of the test results
Normal concentration:
<7% (1% lower limit of detectability)
<15% (heavy smoker)
Toxic concentration: > or =20%
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
No significant cautionary statements
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
1. Lovejoy FH Jr, Linden CH: Acute poison and drug overdosage: carbon monoxide. In Harrison's Principles of Internal Medicine. Twelfth Edition. Edited by JD Wilson, E Braunwald, KJ Isselbacher, et al. New York, McGraw-Hill Book Company, 1991, pp 2171-2172
2. Carbon monoxide intoxication--a preventable environmental health hazard. Mor Mortal Wkly Rep 1982;31:529-531
Method Description Describes how the test is performed and provides a method-specific reference
The ITC AVOXimeter 4000 illuminates whole blood samples with multiple wavelengths, records the optical density of the samples at each of the wavelengths, and computes carboxyhemoglobin (%COHb) results. This method reduces interferences from dyshemoglobin, fetal hemoglobin, and bilirubin, and minimizes the effects of hemolysis.(Operator's Manual, AVOXimeter 4000 Whole Blood Oximeter, AP4001 10/07, International Technidyne Corporation, 8 Olsen Avenue, Edison, NJ 08820)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Friday; 12 a.m.
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
82375
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| 8649 | Carbon Monoxide, B | 20563-3 |
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