Test ID: DSS
Drug Screen, Prescription/OTC, Serum
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Detection and identification of prescription or over the counter drugs frequently found in drug overdose or used with a suicidal intent
This test is designed to qualitatively identify drugs present in the specimen; quantification of identified drugs, when available, may be performed upon client request
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
Gas Chromatography-Mass Spectrometry (GC-MS)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
Acetaminophen (Tylenol)
Acetohexamide (Dymelor)
Acetylsalicylate (Aspirin)
Advil (Ibuprofen)
Allobarbital (Dialog)
Alprazolam (Xanax)
Alurate (Aprobarbital)
Ambien (Zolpidem)
Amitriptyline (Elavil)
Amobarbital (Amytal)
Anacin-3 (Acetaminophen)
Anafranil (Clomipramine)
Ansaid (Flurbiprofen)
Antipyrine
ASA (Aspirin)
Atarax (Hydroxyzine)
Ativan (Lorazepam)
Barbita (Phenobarbital)
Barbital
Benadryl (Diphenhydramine)
Bentyl (Dicyclomine)
Benztropine (Cogentin)
Brompheniramine (Dimetane, Dimetapp Allergy, Nasahist B, ND-Stat, Oraminic II)
Bupropion (Amfebutamone, Wellbutrin, Zyban)
Butabarbital (Butisol)
Butalbital (Fiorinal)
Butazolidin (Phenylbutazone)
Butisol (Butabarbital)
Caffeine
Calan (Verapamil)
Carbamazepine (Tegretol)
Cardizem (Diltiazem)
Carisoprodol (Soma)
Celexa (Citalopram)
Celontin (Methsuximide)
Chlor-Trimeton (Chlorpheniramine)
Chlordiazepoxide (Librium)
Chlorpheniramine (Chlor-Trimeton, Efidac, Teldrin)
Chlorproamide (Diabinese)
Chlorzoxazone (Inspra)
Choledyl (Oxtriphylline)
Citalopram (Celexa)
Clinoril (Sulindac)
Clomipramine (Anafranil)
Clorazepate (Tranxene)
Clozapine (Clozaril)
Clozaril (Clozapine)
Codeine
Cogentin (Benztropine)
Compazine (Prochlorperazine)
Cyclobenzaprine (Flexeril)
Dalmane (Flurazepam)
Darvon (Propoxyphene)
Depakote (Valproic Acid)
Desipramine (Norpramin)
Desyrel (Trazodone)
Dextromethorphan
Diabinese (Chlorpropamide)
Diazepam (Valium)
Diclofenac (Voltaren)
Dicyclomine (Bentyl)
Diflucan (Fluconazole)
Dilantin (Phenytoin)
Diltiazem (Cardizem)
Dimetane (Brompheniramine)
Dimetapp Allergy (Brompheniramine)
Diphenhydramine (Benadryl)
Diprivan (Propofol)
Disopyramide (Norpace)
Divalproex
Dolophine (Methadone)
Doriden (Glutethimide)
Doxepin (Sinequan)
Doxylamine (Unisom)
Dypropylacetic Acid
Effexor (Venlafaxine)
Efidac (Chlorpheniramine)
Equanil (Meprobamate)
Ethchlorvynol (Placidyl)
Ethosuximide (Zarontin)
Excedrin (Acetaminophen)
Felbamate (Felbatol)
Felbatol (Felbamate)
Fenesin (Guaifenesin)
Fenoprofen (Nalfon)
Fiorinal (Butalbital)
Flagyl (Metronidazole)
Fluconazole (Diflucan)
Fluoxetine (Prozac)
Flurazepam (Dalmane)
Flurbiprofen (Ansaid)
Gabapentin (Neurontin)
Gabitril (Tiagabine)
Gemfibrozil (Lopid)
Gemonil (Metharbital)
Glutethimide (Doriden)
Guaifenesin (Fenesin, Humibid, Humibid LA, Mucinex, Organidin NR, Robitussin)
Humibid (Guaifenesin)
Humibid LA (Guaifenesin)
Hydroxy-Ethyl Flurazepam (Metabolite of Flurazepam) (Dalmane)
Hydroxyzine (Atarax)
Imipramine (Tofranil)
Indocin (Indomethacin)
Indomethacin (Indocin)
Inspra (Chlorzoxazone)
Isoptin (Verapamill)
Keppra (Levetiracetam)
Ketoprofen (Orudis)
Ketorolac (Toradol)
Kutrase (Phenyltoloxamine)
Lamictal (Lamotrigine)
Lamotrigine (Lamictal)
Levetiracetam (Keppra)
Lexapro (Citalopram)
Librium (Chlordiazepoxide)
Lidocaine (Xylocaine)
Lopid (Gemfibrozil)
Lorazepam (Ativan)
Ludiomil (Maprotiline)
Luminal (Phenobarbital)
Mebaral (Mephobarbital)
Mephobarbital (Mebaral)
Meprobamate (Miltown)
Methadone (Dolophine)
Methaqualone (Parest, Quaalude, Sopor)
Metharbital (Gemonil)
Methyl Salicylate
Methyprylon (Noludar)
Metoclopramide (Reglan)
Metronidazole (Flagyl)
MHC (Oxcarbazepine Metabolite)
MHD (Oxcarbazepine Metabolite)
Mirtazapine (Remeron)
Monohydroxy Carbamazepine
Motrin (Ibuprofen)
Mysoline (Primidone)
N-Desmethyl Methsuximide (Metabolite of Methsuximide)
Nabumetone (Relafen)
Nalfon (Fenoprofen)
Naprosyn (Naproxen)
Naproxen (Naprosyn)
Nasahist B (Brompheniramine)
ND-Stat (Brompheniramine)
Nembutal (Pentobarbital)
Neurontin (Gabapentin)
Noludar (Methyprylon)
Nordizepam (Tranxene)
Norpace (Disopyramide)
Norpramin (Desipramine)
Norpropoxyphene (Metabolite of Propoxyphene) (Darvon)
Nortriptyline (Pamelor)
Nuprin (Ibuprofen)
Oraminic II (Brompheniramine)
Organidin NR (Guaifenesin)
Orinase (Tolbutamide)
Orudis (Ketoprofen)
Oxazepam (Serax)
Oxcarbazepine Metabolite (MHC)
Oxcarbazepine Metabolite (MHD)
Oxtriphylline (Choledyl)
Pamelor (Nortriptyline)
Parest (Methaqualone)
Paroxetine (Paxil)
Paxil (Paroxetine)
Pentazocine (Talwin)
Pentobarbital (Nembutal)
Pentothal (Thiopental)
Phenergan (Promethazine)
Phenobarbital
Phenylbutazone (Butazolidin)
Phenyltoloxamine (Kutrase)
Phenytoin (Dilantin)
Placidyl (Ethchlorvynol)
Prescription Drug Screen
Primidone (Mysoline)
Prochlorperazine (Compazine)
Promethazine (Phenergan)
Propofol (Diprivan)
Propoxyphene (Darvon)
Prozac (Fluoxetine)
Quaalude (Methaqualone)
Quetiapine (Seroquel)
Quinidex (Quinidine)
Quinidine (Quinidex)
Reglan (Metoclopramide)
Relafen (Nabumetone)
Remeron (Mirtazapine)
Restoril (Temazepam)
Robitussin (Guaifenesin)
Salicylate
Secobarbital (Seconal)
Seconal (Secobarbital)
Seroquel (Quetiapine)
Sertraline (Zoloft)
Sinequan (Doxepin)
SloPhyllin (Theophylline)
Solfoton (Phenobarbital)
Soma (Carisoprodol)
Somophyllin (Theophylline)
Sopor (Methaqualone)
Strychnine
Sulindac (Clinoril)
Surmontil (Trimipramine)
Talwin (Pentazocine)
TCA (Tricyclic Antidepressants)
Tegretol (Carbamazepine)
Teldrin (Chlorpheniramine)
Temazepam (Restoril)
Theo-Dur (Theophylline)
Thiopental (Pentothal)
Tiagabine (Gabitril)
Ticlid (Ticlopidine)
Ticlopidine (Ticlid)
Tigan (Trimethobenzamide)
Tofranil (Imipramine)
Tolazamide (Tolinase)
Tolbutamide (Orinase)
Tolectin (Tolmetin)
Tolinase (Tolazamide)
Tolmetin (Tolectin)
Topamax (Topiramate)
Topiramate (Topamax)
Toradol (Ketorolac)
Tramadol (Ultram)
Tranxene (Clorazepate)
Trental (Pentoxyfilline)
Tricyclic Antidepressants (TCA)
Trileptal (Oxcarbazepine)
Trimethobenzamide (Tigan)
Trimipramine (Surmontil)
Tuinal (Amobarbital and Secobarbital)
Ultram (Tramadol)
Unisom (Doxylamine)
Valium (Diazepam)
Valproate
Valproic Acid (Depakene)
Valproic Acid (Depakote)
Venlafaxine (Effexor)
Verapamil (Calan)
Verelan (Verapamil)
Versed (Midazolam)
Voltaren (Diclofenac)
Wellbutrin (Bupropion)
Xylocaine (Lidocaine)
Zarontin (Ethosuximide)
Zoloft (Sertraline)
Zonegran (Zonisamide)
Zonisamide (Zonegran)
Zyban (Bupropion)
Zyprexa (Olanzapine)
Aminophylline
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Container/Tube: Red top
Specimen Volume: 5.25 mL
Additional Information:
1. See Table 1 in Prescription and Over-the-Counter (OTC) Drug Screens in Special Instructions.
2. For situations where chain-of-custody is required, a Chain-of-Custody Kit (Supply T282) is available. For chain-of-custody information, see COCH/9426 Chain-of-Custody Processing.
3. This test is not appropriate for drugs of abuse/illicit drug testing. Cocaine will not be detected in this assay.
4. Not intended for use in employment-related testing.
5. This test is not appropriate for assessment of therapeutic compliance.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | Mild OK; Gross OK |
| Lipemia | Mild OK; Gross OK |
| Icterus | Mild OK; Gross OK |
| Other | Plasma or serum gel tube |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 14 days |
| Frozen | 14 days | |
| Ambient | 3 hours |
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
This test looks for a broad spectrum of prescription and over-the-counter (OTC) drugs. It is designed to detect drugs that have toxic effects, as well as known antidotes or active therapies that a clinician can initiate to treat the toxic effect. The test is intended to help physicians manage an apparent overdose or intoxicated patient, to determine if a specific set of symptoms might be due to the presence of drugs, or to evaluate a patient who might be abusing these drugs intermittently. The test is not designed to screen for intermittent use of illicit drugs.
Drugs of toxic significance that are not detected by this test are: digoxin, lithium, and many drugs of abuse/illicit drugs, some benzodiazepines, and most opiates.
See Prescription and Over-the-Counter (OTC) Drug Screens Table 1 in Special Instructions.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Drug detection
Interpretation Provides information to assist in interpretation of the test results
The drugs we know can be detected by this test are listed in Prescription and Over-the-Counter (OTC) Drug Screens Table 1 in Special Instructions.
The pharmacology of each drug determines how the test should be interpreted. A detailed discussion of each drug is beyond the scope of this text. If you wish to have a report interpreted, please call Mayo Medical Laboratories and ask for a toxicology consultant.
Mayo Medical Laboratories will only report reference ranges that we have determined to be clinically correlated. Other reference ranges are available from the literature, but since we have not validated them, we choose not to report them. We will gladly discuss them during a consultation and provide reference citations if requested.
Each report will indicate the drugs detected.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Not intended for therapeutic compliance testing.
Not intended for use in employment-related testing.
Not intended for drugs of abuse/illicit drug testing.
Not all drugs can be quantitatively extracted from the specimen, so accurate quantification may not be possible, and many do not have reference ranges.
For situations where chain-of-custody is required, a Chain-of-Custody Kit (Supply T282) is available. See COCH/9426 Chain-of-Custody-Processing.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Porter WH: Clinical toxicology. In Tietz Textbook of Clinical Chemistry and Molecular Diagnostice. 4th edition. Edited by CA Burtis, ER Ashwood. DE Bruns St. Louis, MO, Elsevier Saunders, 2006, pp 1287-1369
Method Description Describes how the test is performed and provides a method-specific reference
Screening is by gas chromatography-mass spectroscopy. (Unpublished Mayo method)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Sunday; Varies
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
80100-Drug screen, qualitative, each procedure
G0431-Drug screen, qualitative, each specimen-government payers (if appropriate)
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| 31072 | Drugs detected: | 20785-2 |
| 31168 | Chain of Custody | In Process |
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