Test ID: NEEVP
Neurologic Enzyme Evaluation
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Evaluating patients who have a hemolytic process that is associated with some neurologic findings
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| NEEV | Neurologic Enzyme Interpretation | No | Yes |
| GLTI | Glutathione, B | No | Yes |
| PFK | Phosphofructokinase, RBC | No | Yes |
| PGK | Phosphoglycerate Kinase, B | No | Yes |
| TPI | Triosephosphate Isomerase, B | No | Yes |
| P5NT | Pyrimidine 5' Nucleotidase, B | Yes | Yes |
Method Name A short description of the method used to perform the test
NEEV/13083: Consultative Interpretation
GLTI/2635, PFK/80188, PGK/2653, TPI/2633, P5NT/80650: Kinetic Spectrophotometry (KS)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Container/Tube: Yellow top (ACD)
Specimen Volume: 10 mL
Collection Instructions: Do not transfer blood to other containers.
Forms: If not ordering electronically, please submit a Hematopathology/Molecular Oncology Request Form (Supply T241) with the specimen.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | Mild OK; Gross reject |
| Lipemia | NA |
| Icterus | NA |
| Other | NA |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| Whole Blood ACD-B | Refrigerated | 8 days |
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Several RBC enzymes are known to cause a nonspherocytic hemolytic anemia (HA). The most common cause of these are glucose-6-phosphate dehydrogenase and pyruvate kinase deficiency. Four other RBC enzymes that cause HA have also been associated with hereditary myopathic or neurologic disorders. These enzymes are phosphofructokinase, triosephosphate isomerase, phosphoglycerate kinase, and glutathione synthase. Kinetic enzyme assays are available for the first 3 disorders. Quantitative measurement of glutathione substitutes for analysis of the enzyme glutathione synthase.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Definitive results and an interpretive report will be provided.
Interpretation Provides information to assist in interpretation of the test results
Definitive results and an interpretive report will be provided.
Significant abnormal values typically are 25% of values obtained for a normal individual.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
No significant cautionary statements
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
1. Fairbanks VF, Klee GG: Biochemical aspects of hematology. In Tietz Textbook of Clinical Chemistry. Third edition. Edited by CA Burtis, ER Ashwood. Philadelphia, WB Saunders Company, 1999, pp 1642-1644
2. Boulard MR, Meienhofer MC, Bois M, et al: Letter: red-cell phosphofructokinase deficiency. N Engl J Med 1974;291:978-979
3. Schneider AS, Valentine WN, Hattori M, Heins HL: Hereditary hemolytic anemia with triosephosphate isomerase deficiency. N Engl J Med 1965;272:229-235
Method Description Describes how the test is performed and provides a method-specific reference
See Individual Unit Codes
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Friday; Varies
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
82657-RBC enzymes
82978-Glutathione
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| 2734 | Pyrimidine 5' Nucleotidase, B | 2902-5 |
| 2635 | Glutathione, B | 2383-8 |
| PFK_ | Phosphofructokinase, RBC | 44052-9 |
| PGK_ | Phosphoglycerate Kinase, B | 44053-7 |
| TPI_ | Triosephosphate Isomerase, B | 44054-5 |
| 13083 | Neurologic Enzyme Interpretation | In Process |
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