Test ID: FSS
Fungal Antibody Survey, Serum
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Screening for antibodies to dimorphic fungi (Blastomyces, Coccidioides, Histoplasma) and the antigen of Cryptococcus neoformans during infection
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SCOC | Coccidioides Ab, S | Yes | Yes |
| SCRYP | Cryptococcus Ag Screen, S | Yes | Yes |
| HISTO | Histoplasma Ab Screen, S | Yes | Yes |
| SBLAS | Blastomyces Ab, EIA, S | Yes | Yes |
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SCRYR | Cryptococcus Ag, S | Yes | No |
| SHSTO | Histoplasma Ab, S | Yes | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
If Histoplasma capsulatum antibody screen result is equivocal or positive (by enzyme-linked immunosorbent assay), then complement fixation/immunodiffusion testing (SHSTO/26692 Histoplasma Antibody, Serum) will be performed at an additional charge.
If Cryptococcus antigen screen result is reactive (by EIA), then latex agglutination testing (SCRYR/28071 Cryptococcus Antigen, Serum) will be performed at an additional charge.
Method Name A short description of the method used to perform the test
SCOC/8295: Complement Fixation (CF) Using Coccidioidin: IgG/Immunodiffusion: IgG and IgM
SCRYP/86167, SBLAS/86691: Enzyme Immunoassay (EIA)
HISTO/83853: Enzyme-Linked Immunosorbent Assay (ELISA)
SHSTO/26692: Complement Fixation (CF)/Immunodiffusion
SCRYR/28071: Latex Agglutination
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
Fungus Serology
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Specimen Volume: 3 mL
Forms: If not ordering electronically, submit a General Request Form (Supply T239) with the specimen.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | Mild OK; Gross reject |
| Lipemia | Mild OK; Gross reject |
| Icterus | NA |
| Other | NA |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 14 days |
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
See individual test IDs.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Blastomyces ANTIBODY BY EIA
Negative
Coccidioides ANTIBODY
Complement fixation: negative
If positive, results are titered.
Immunodiffusion: negative
Results are reported as positive, negative, or equivocal.
Cryptococcus ANTIGEN SCREEN
Negative
If reactive, results are titered under the reflex test.
Histoplasma ANTIBODY SCREEN
Negative
Interpretation Provides information to assist in interpretation of the test results
See individual test IDs.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Cross-reacting antibodies may be produced and sometimes present interpretive problems.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Kaufman L, Kovacs JA, Reiss E: Clinical immunomycology. In Manual of Clinical and Laboratory Immunology, Washington, DC, ASM Press, 1992
Method Description Describes how the test is performed and provides a method-specific reference
See individual unit codes.
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Blastomyces antibody: Monday through Friday, Sunday; 11 a.m.
Coccidioides antibody: Monday through Friday; 11 a.m.
Cryptococcus antigen: Monday through Friday; 11 a.m.
Histoplasma antibody: Monday through Friday; 11 a.m.
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
86612-Blastomyces
86635 x 3-Coccidioides
86698-Histoplasma
87327-Cryptococcus EIA
86403-Cryptococcus latex agglutination (if appropriate)
86698 x 3-Histoplasma (if appropriate)
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| HISTO | Histoplasma Ab Screen, S | 44522-1 |
| SBLAS | Blastomyces Ab, EIA, S | 7816-2 |
| SCRYP | Cryptococcus Ag Screen, S | 29903-2 |
| 8295 | Cocci Complement F | 5096-3 |
| 21649 | Cocci Immunodiffusion-IgG | 62458-5 |
| 21648 | Cocci Immunodiffusion-IgM | 62459-3 |
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