Test ID: SRSV
Respiratory Syncytial Virus (RSV) Antibodies, IgG and IgM (Separate Determinations), Serum
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Aiding in the diagnosis of a recent respiratory syncytial virus infection
Method Name A short description of the method used to perform the test
Immunofluorescence
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
RSV (Respiratory Syncytial Virus) Antibody
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Specimen Volume: 0.5 mL
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | Mild OK; Gross reject |
| Lipemia | Mild OK; Gross reject |
| Icterus | NA |
| Other | NA |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 14 days |
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Respiratory syncytial virus (RSV) is an important cause of human respiratory infection. It strikes most frequently and severely in the very young and is a common cause of bronchiolitis, pneumonia, or croup in young infants. Infections in older children and adults tend to be milder and to involve the upper respiratory tract. RSV infections are seasonal, from late fall to spring, and often occur in epidemic form.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
IgG: <1:10
IgM: <1:10
The presence of IgM class antibodies or a 4-fold or greater rise in paired sera IgG titer indicates recent infection. The presence of demonstrable IgG generally indicates past exposure and immunity.
Interpretation Provides information to assist in interpretation of the test results
Normals:
-IgG: <1:10
-IgM: <1:10
The presence of IgM class antibodies or a 4-fold or greater rise in paired sera IgG titer indicates recent infection.
The presence of demonstrable IgG generally indicates past exposure and immunity.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
For low IgG antibody levels with no demonstrable IgM, it is recommended that a convalescent specimen be drawn in 2 to 4 weeks.
Not useful for diagnosis from spinal fluid.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Tristram DA, Welliver RC: Respiratory syncytial virus. In Manual of Clinical Microbiology. 7th edition. Edited by PR Murray, EJ Baron, MA Pfaller, et al. Washington, DC, American Society for Microbiology, 1999, pp 942-950
Method Description Describes how the test is performed and provides a method-specific reference
The indirect immunofluorescence test is used for the measurement of IgG and IgM antibodies to respiratory syncytial virus (RSV). Specific antibodies present in the serum of the patient react with RSV infected cells that have been previously fixed on a glass microscope slide. Fluorescein-labeled anti-human IgG or IgM conjugate is used to stain specific antibody bound to the substrate cells. The slides are examined with a fluorescence microscope for the characteristic apple-green fluorescence of the infected cells. (Urquhardt GE, Walker GH: Immunofluorescence for routine diagnosis of respiratory syncytial virus infection. J Clin Pathol 1972;25:843-845)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Tuesday, Friday; 9 a.m.
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
86756 x 2
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| 5737 | Respiratory Syncytial Virus, IgG | 9573-7 |
| 5738 | Respiratory Syncytial Virus, IgM | 9574-5 |
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