Cysticercosis, IgG Antibody, Western Blot Assay, Serum
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
An aid in the diagnosis and confirmation of cysticercosis
Western Blot Assay
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Cysticercosis, IgG Ab, West Blot, S
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Preferred: Red top
Acceptable: Serum gel
Specimen Volume: 0.2 mL
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Mild OK; Gross reject
Mild OK; Gross reject
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
|Serum||Refrigerated (preferred)||14 days|
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Cysticercosis is an infection by the larval form of the tapeworm, Taenia solium. The adult tapeworm resides in the intestines of pigs or humans and eggs are excreted in the feces.
In areas with poor sanitation, tapeworm eggs contained in food or water are ingested and the larva are liberated in the small intestine. They then migrate through the intestinal wall to various tissues, including the brain, where they encyst. This cysticercus produces disease by functioning as a space occupying mass.
Cerebrospinal cysticercosis can result in seizure disorders or other focal neurologic signs. Cysticercosis is the most common cause of such findings in some Latin American countries.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
A positive Western blot suggests the presence of cysticercosis.
A single positive antibody result only indicates previous immunological exposure. Antibody response is highly variable in regard to cyst location and each individual.
A negative test result does not necessarily rule out infection. Patients with a single enhancing or calcified parenchymal cyst can be negative.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Test results should be used in conjunction with clinical evaluation and information.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
1. Diaz F, Garcia HH, Gilman RH, et al: Epidemiology of taeniasis and cysticercosis in a Peruvian village. Am J Epidemiol 1992 Apr 15;135(8):875-882
2. Flisser A: Taeniasis and cysticercosis due to Taenia solium. Prog Clin Parasitol 1994;4:77-116
Method Description Describes how the test is performed and provides a method-specific reference
The Western blot assay uses Taenia solium glycoprotein antigens bound to nitrocellulose strips that are incubated with patient sera. Bound antibodies are detected by the addition of enzyme anti-human IgG conjugate followed by its chromogenic substrate, which precipitates as a purple-colored band. Detection of antibodies to any of the seven specific Taenia solium antigen bands (50, 42, 39, 24, 21, 18, 14, 13 kDa) is interpreted as a positive assay result.(Package insert: Cysticercosis Western Blot Assay Kit. Immunetics, Cambridge, MA; Wilson M, Bryan RT, Fried JA: Clinical evaluation of the cysticercosis enzyme-linked immunoelectrotransfer blot in patients with neurocysticercosis. J Infect Dis 1991;164:1007-1009)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Tuesday, Thursday; 8 a.m.
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Same day/1 day
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
This test uses a reagent or kit labeled by the manufacturer as Research Use Only. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
|Result ID||Reporting Name||LOINC Code|
|81354||Cysticercosis, IgG Ab, West Blot, S||6374-3|