Test ID: PENG
Penicillin G, Serum
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Monitoring penicillin G therapy to ensure absorption or clearance
Evaluating patient compliance
Method Name A short description of the method used to perform the test
High-Performance Liquid Chromatography (HPLC)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Collection Container/Tube: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Serum for a peak level should be drawn 30 to 60 minutes after dosing. Serum for a trough level should be drawn no more than 30 minutes before the next dose.
2. Spin down within 2 hours of draw.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | Mild OK; Gross reject |
| Lipemia | Mild OK; Gross reject |
| Icterus | Mild OK; Gross reject |
| Other | Serum gel tube |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Frozen | 14 days |
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Penicillin G is used for treatment of infections by gram-positive bacteria such as Entercoccus faecalis, Staphylococcus species, Streptococcus pneumonia, and beta-hemolytic strains of streptococcus. Penicillin G has a wide therapeutic index and dose-dependent toxicity. Target peak serum concentrations vary according to the susceptibility of the organism, ie, the minimum inhibitory concentration.
Routine drug monitoring is not indicated in all patients. Penicillin G is less well absorbed than other beta-lactam antibiotics; thus, this assay may be useful in ensuring adequate oral dosing. Penicillin accumulates in patients with renal failure, and monitoring may be useful to prevent concentration-dependent toxicity.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Peak: 2.0-20.0 mcg/mL
Interpretation Provides information to assist in interpretation of the test results
Most individuals display optimal response to Penicillin G when peak serum levels (drawn 30-60 minutes after a dose) are between 2.0 mcg/mL and 20.0 mcg/mL. Highly susceptible organisms (minimum inhibitory concentration [MIC] <0.06 mcg/mL) will respond at low penicillin serum concentrations; resistant bacteria require higher drug concentrations, depending on the MIC of the specific organism.
The risk of toxicity increases with serum concentrations >20.0 mcg/mL.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
1. Bryan C, Talwani R, Stinson M: Penicillin dosing for pneumococcal pneumonia. Chest 1997 Dec;112:1657-1664
2. Mandell GL: Principles and Practice of Infectious Diseases. Churchill Livingstone Press, London, 1995
3. Moyer TP: Therapeutic drug monitoring. In Tietz Fundamentals of Clinical Chemistry. 5th edition. Edited by CA Burtis, ER Ashwood, Philadelphia, WB Saunders Company, 2001, pp 608-635
Method Description Describes how the test is performed and provides a method-specific reference
High-performance liquid chromatography (HPLC). (Unpublished Mayo method)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Tuesday; 9:00 a.m.
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
82491
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| 80134 | Penicillin G, S | 3913-1 |
External
link
PDF
document
Excel
document
Word
document