Hematologic Disorders, Chromosome Hold, Bone Marrow or /Peripheral Blood
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Holding the bone marrow or peripheral blood specimen in the laboratory but delay chromosome analysis while preliminary morphologic assessment is in process
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
|Test ID||Reporting Name||Available Separately||Always Performed|
|BM||Chromosomes, Hematolog, Bone Marrow||Yes||No|
|HBL||Chromosomes, Hematologic, Blood||Yes||No|
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
This test is designed to hold the specimen but delay chromosome preparation and analysis while preliminary morphologic assessment is in process.
Upon specimen receipt, the specimen will be held in the laboratory. Chromosome analysis will be performed unless the test is canceled (see cancellation policy).
If the client notifies the laboratory that chromosome analysis is not necessary, this test will be reported as "canceled." Chromosome analysis will not be performed but a processing fee will be charged.
If the client does not notify the laboratory that chromosome analysis is not needed (see cancellation policy), the Heme Chromosome Hold test will be reported as "reflexed" and chromosome analysis will be performed. Depending on the specimen received, the appropriate reflex test will be performed. No processing fee will be assessed for this test as culture charges are included in the reflexed test.
Cancellation policy: The test may be canceled by 4 p.m. (central time) 2 business days after the specimen was collected. The client must notify Mayo Medical Laboratories at 800-533-1710 within this time period to cancel chromosome analysis. If no cancellation is received by this time, chromosome analysis will be performed and charged. Weekend communication can be deferred until Monday.
Direct preparation of specimen
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Heme Chromosome Hold, B/BM
Bone marrow cell culture
Peripheral blood cell culture
Peripheral blood cell culture
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Provide a reason for referral with each specimen and bone marrow pathology report (if available). The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.
Advise Express Mail or equivalent if not sent via courier service.
Specimen Type: Bone marrow
Container/Tube: Green top (sodium heparin)
Specimen Volume: 2-3 mL
1. It is preferable to send the first aspirate from the bone marrow collection.
2. Invert several times to mix bone marrow.
3. Other anticoagulants are not recommended and are harmful to the viability of the cells.
Specimen Type: Peripheral blood
Container/Tube: Green top (sodium heparin)
Specimen Volume: 5-10 mL
1. Invert several times to mix blood.
2. Other anticoagulants are not recommended and are harmful to the viability of the cells.
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Conventional chromosome analysis is the gold standard for identification of the common, recurrent chromosome abnormalities for most hematologic malignancies. Based on morphologic review of the bone marrow or peripheral blood specimen by a hematopathologist, a determination of additional appropriate testing can be made. If the specimen does not show evidence of malignancy, chromosome analysis may not be necessary. Depending on the diagnosis, FISH assays may also be more informative.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
If notified by the client, this test may be canceled and a processing fee assessed.
If no notification to cancel testing is received, this test will be reported as "reflexed for chromosome analysis" and depending on the specimen received, BM/8506 Chromosome Analysis, Hematologic Disorders, Bone Marrow or HBL/8537 Chromosome Analysis, Hematologic Disorders, Blood will be performed and an interpretive report provided.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
This test does not apply to any FISH assays. If specimen is to be held for FISH testing, HFH/7874 Hematologic Disorders, Fluorescence In Situ Hybridization (FISH) Hold, Bone Marrow or /Peripheral Blood must be ordered.
Method Description Describes how the test is performed and provides a method-specific reference
The specimen will be held in the laboratory while preliminary morphologic assessment is in process to determine if chromosome analysis is appropriate. If needed, cell culture and chromosome analysis will be performed.
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Friday; 6 a.m.-9 p.m., Saturday, Sunday; 6 a.m.-4 p.m.
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Original specimen - 3 weeks
Performing Laboratory Location The location of the laboratory that performs the test
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
See individual reflex tests
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
|Result ID||Reporting Name||LOINC Code|
|51355||Reason For Referral||42349-1|