Test ID: FRDP
Rickettsial Disease Panel
NY State Approved 
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| FRTGM | R. Typhi IgG/IgM Reflex to Titers | No | Yes |
| FRMGM | RMSF IgG/IgM Reflex to Titers | No | Yes |
| FQGI | Q Fever IgG Phase I Screen | No | Yes |
| FQG2S | Q Fever IgG Phase II Screen | No | Yes |
| FQMI | Q Fever IgM Phase I Screen | No | Yes |
| FQM2S | Q Fever IgM Phase II Screen | No | Yes |
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| FRTG | R. Typhi IgG Titer | No | No |
| FRTM | R. Typhi IgM Titer | No | No |
| FRMFG | RMSF IgG Titer | No | No |
| FRMFM | RMSF IgM Titer | No | No |
| FQFG1 | Q Fever IgG Phase I Titer | No | No |
| FQFG2 | Q Fever IgG Phase II Titer | No | No |
| FQFM1 | Q Fever IgM Phase I Titer | No | No |
| FQFM2 | Q Fever IgM Phase II Titer | No | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
If R. Typhi IgG is Detected - FRTG Rickettsia (Typhus Fever) IgG Titer will be performed at an additional charge.
If R. Typhi IgM is Detected - FRTM Rickettsia (Typhus Fever) IgM Titer will be performed at an additional charge.
If RMSF IgG is Detected - FRMFG Rickettsia (RMSF) IgG Titer will be performed at an additional charge.
If RMSF IgM is Detected - FRMFM Rickettsia (RMSF) IgM Titer will be performed at an additional charge.
If Q Fever IgG Phase I (FQGI) is Positive – FQFG1 Q Fever IgG Phase I Titer will be performed at an additional charge.
If Q Fever IgM Phase I (FQMI) is Positive – FQFG2 Q Fever IgM Phase I Titer will be performed at an additional charge.
If Q Fever IgG Phase II (FQG2S) is Positive – FQFM1 Q Fever IgG Phase II Titer will be performed at an additional charge.
If Q Fever IgM Phase II (FQM2S) is Positive – FQFM2 Q Fever IgM Phase II Titer will be performed at an additional charge.
Method Name A short description of the method used to perform the test
Immunofluorescence Assay (IFA)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Draw blood in a plain red-top or serum gel tube(s). Spin down and send 2 mL of serum refrigerated.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis: | Mild OK, Gross Reject |
| Thawing: | NA |
| Lipemia: | Mild OK; Gross Reject |
| Icterus: | NA |
| Other: | NA |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 30 days | |
| Ambient | 7 days |
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
R. Typhi IgG/IgM
RMSF IgG/IgM
Reference Range: Not Detected
Q Fever IgG/IgM Phase I/II Screens
Reference Range: Negative
Q Fever Antibody testing includes differentiation of antibodies to Phase I and Phase II antigenic variants. Coxiella burnetii, which causes Q Fever, undergoes transitions between Phase I and Phase II states. These phases are serologically distinguishable and useful in the serodiagnosis of acute and chronic disease.
In some cases, the ratio of titer of phase II to phase I may indicate the stage of the disease. A ratio of greater than 1 may indicate the acute stage; greater than or equal to 1, granulomatous hepatitis; and less than 1, the chronic stage or endocarditis.
As with other infectious diseases, IgM antibodies are the first to appear. Usually they are detectable for a few weeks or, at the most, for a few months. IgG antibodies appear somewhat later but can persist for years, even for life.
Although single phase II IgG titers of 1:256 or greater are considered evidence of acute C. burnetii disease, the best criterion for a dependable diagnosis is still the demonstration of a fourfold or higher increase in antibody titer between the acute and convalescent serum samples.
Test Performed By: Focus Diagnostics, Inc.
5785 Corporate Avenue
Cypress, CA 90630-4750
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Friday
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Performing Laboratory Location The location of the laboratory that performs the test
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
86638/x4 Q Fever
86757/x4 Rickettsia
86638/each Q Fever titer (if appropriate)
86757/each Rickettsia titer (if appropriate)
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| Z3177 | R. Typhi IgG | In Process |
| Z3179 | RMSF IgG | In Process |
| FQGI | Q Fever IgG Phase I Screen | In Process |
| FQG2S | Q Fever IgG Phase II Screen | In Process |
| FQMI | Q Fever IgM Phase I Screen | In Process |
| FQM2S | Q Fever IgM Phase II Screen | In Process |
| Z3180 | RMSF IgM | In Process |
| Z3178 | R. Typhi IgM | In Process |
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