Test ID: 5362
Endomyocardial Biopsy
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Evaluation of:
-Cardiac allograft rejection
-Cardiomyopathies
-Myocarditis
-Idiopathic arrhythmias
-Idiopathic chest pain
-Anthracycline cardiotoxicity
-Secondary heart disease (amyloidosis, sarcoidosis, hemochromatosis, storage diseases, and neoplastic diseases)
Method Name A short description of the method used to perform the test
Light Microscopy
Includes hematoxylin-and-eosin, Gomori's iron, and sulfated alcian blue stains.
Electron microscopy, immunoperoxidase, and immunofluorescence are available upon special request. For special studies, call BEFORE the biopsy is performed.
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
Heart Biopsy
Myocardial Biopsy
Skin Biopsy
MCBX
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Container/Tube: Sterile container with 10% neutral buffered formalin, Trump's solution, or tissue embedded in paraffin
Specimen Volume: Entire specimen
Collection Instructions: For the evaluation of adriamycin cardiotoxicity, specimens should be fixed in glutaraldehyde or Trump's solution. These specimens will be evaluated by transmission electron microscopy at an additional charge.
Additional Information: The clinical differential diagnoses and the name and phone number of the pathologist or cardiologist involved with the case are required.
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | NA |
| Lipemia | NA |
| Icterus | NA |
| Other | NA |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| Tissue | Ambient (preferred) | |
| Refrigerated | ||
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Endomyocardial biopsies may be indicated to evaluate a variety of cardiac disorders. The procedure is performed using a device inserted through the jugular, subclavian, or femoral vein.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Abnormalities will be compared to reported reference values.
Interpretation Provides information to assist in interpretation of the test results
This request will be processed as a consultation. Appropriate stain(s) will be performed and a diagnostic interpretation provided.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Either wet tissue fixed in 10% neutral buffered formalin or Trump's solution or slides and paraffin blocks may be submitted.
Electron microscopy is generally only performed for the evaluation of adriamycin cardiotoxicity and storage diseases. For the evaluation of adriamycin cardiotoxicity, specimens should be fixed in glutaraldehyde or Trump's solution.
Clinical diagnosis must be submitted with the specimen.
Not useful for distinguishing between alcoholic cardiomyopathy and idiopathic dilated cardiomyopathy.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Edwards WD, Holmes DR Jr: Transvenous endomyocardial biopsy. In Mayo Clinic Practice of Cardiology: Fundamentals and Practice. 3rd edition. Edited by ER Giuliani, BJ Gersh, MD McGooh, et al. St. Louis, MO, Mosby-Yearbook, 1996, pp 672-688
Method Description Describes how the test is performed and provides a method-specific reference
The procedure consists of processing for light microscopy and appropriate stains. In selected cases, immunohistochemical stains or transmission electron microscopy may be indicated. (Edwards WD, Holmes DR Jr: Transvenous endomyocardial biopsy. In Mayo Clinic Practice of Cardiology: Fundamentals and Practice. 3rd edition. Edited by ER Giuliani, BJ Gersh, MD McGooh, et al. St. Louis, MO, Mosby-Yearbook, 1996, pp 672-688)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Friday
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Performing Laboratory Location The location of the laboratory that performs the test
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
88325
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| 18463 | Accession Number | N/A |
| 18464 | Referring Pathologist/Physician | 46608-6 |
| 18465 | Ref Path/Phys Address | In Process |
| 18466 | Place of Death: | 21987-3 |
| 18467 | Date and Time of Death: | 31211-6 |
| 18468 | Date of Autopsy: | In Process |
| 18469 | Specimen: | 31208-2 |
| 18470 | Material: | 19139-5 |
| 18471 | Tissue Description: | 22634-0 |
| 18472 | Microscopic Description: | In Process |
| 18473 | Clinical History: | In Process |
| 18474 | Final Diagnosis: | 34574-4 |
| 18991 | Final Diagnosis: | 34574-4 |
| 18475 | Comment: | 48767-8 |
| 18476 | Revision Description: | In Process |
| 18477 | Signing Pathologist: | 19139-5 |
| 18478 | Special Procedures: | N/A |
| 18479 | SP Signing Pathologist: | N/A |
| 18480 | *Previous Report Follows* | N/A |
| 18481 | Addendum: | 35265-8 |
| 19191 | Addendum Comment: | 22638-1 |
| 18482 | Addendum Pathologist: | 19139-5 |
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