Peripheral Nerve Pathology Consultation
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Evaluating diseases of the nerve and disorders that affect nerve function
This consultation is for slides or fixed tissue.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Nerve Biopsy Surgical Pathology Consultation and Review of Outside Material
A battery of special stains and teased nerve fiber analysis will be ordered if fixed tissue is provided. Nerve morphometry and electron microscopy to determine diameter size histograms and ultrastructural abnormalities may be performed based on a preliminary review by the neuropathologist.
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Peripheral Nerve Path Consult
Neuropathology Examination of Tissue
Sural Nerve Biopsy
Neuropathology Examination of Tissue
Sural Nerve Biopsy
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Specimen Type: Nerve biopsy tissue, slides, or block
Collection Instructions: Prepare and transport specimen per instructions in Nerve Biopsy Specimen Preparation Instruction Sheet in Special Instructions. A Nerve Biopsy Kit containing fixatives and buffer is available at an additional fee. For ordering information, call 507-284-8065.
1. Tentative clinical diagnosis
2. Name of nerve biopsied
3. Date of biopsy
4. Indication for nerve biopsy
5. Biopsies from same site will be processed as 1 specimen. Biopsies from different sites require separate orders and separate specimen vials.
--3 segments (vials) of left sural nerve are processed as 1 specimen, 1 order number.
--1 left sural nerve and 1 left superficial peroneal nerve requires 2 separate orders.
1. Nerve Biopsy Information Sheet (Supply T458) in Special Instructions
2. If not ordering electronically, submit a Pathology/Cytology Request Form (Supply T246) with the specimen.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Nerve biopsies provide information about nerve fibers and the interstitum of the nerve. Neuropathic abnormalities include decreased density of myelinated fibers, segmental demyelination, and axonal degeneration. Some possible interstitial abnormalities that affect nerves include necrotizing vasculitis and amyloidosis.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
A consultative report will be provided.
The clinical and neurological history is reviewed with the interpretation of the biopsy.
The histologic slides, special stains, and history, along with the physician's report are correlated by a neuropathologist. A written report is issued.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Poor fixation, orientation, and improper handling of the nerve tissue may hinder the neuropathologist's interpretation of the biopsy. See Directions for Preparing Nerve Biopsy Specimens for Study at Mayo in Special Instructions. Kits containing the proper tissue fixatives and buffers are available upon request.
Method Description Describes how the test is performed and provides a method-specific reference
Unpublished Mayo method.
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Friday; Varies
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Performing Laboratory Location The location of the laboratory that performs the test
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
88325-Consultation, comprehensive, with review of records and specimens, with report on referred material
The following CPT codes are used for most biopsies when adequate tissue is provided. Occasionally, additional stains may be required and will be charged separately.
88313 x 7-Congo red, hematoxylin-and-eosin, luxol fast blue-periodic acid schiff, Masson's trichrome, methylene blue, methyl violet, and Turnbull blue stains
88342 x 2-KP-1 macrophage and leukocyte common antigen stains
88362-Teased fibers, preparation and analysis
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
|Result ID||Reporting Name||LOINC Code|
|PNPC||Peripheral Nerve Path Consult||In Process|