Test ID: DPRP
Drug of Abuse, Propoxyphene Screen with GC-MS Confirmation, Urine
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Detecting and confirming drug abuse involving propoxyphene
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| MSPR | Drug of Abuse, Propoxyphene Conf, U | Yes | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
If the propoxyphene screen is >299 ng/mL, then propoxyphene confirmation is performed at an additional charge.
Method Name A short description of the method used to perform the test
DPRP/505345: Enzyme-Multiplied Immunoassay Technique (EMIT)
MSPR/500373: Gas Chromatography-Mass Spectrometry (GC-MS)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
Propoxyphene DAU Screen, Urine
Darvon (Propoxyphene)
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Container/Tube: Plastic, 60-mL urine bottle
Specimen Volume: 20 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | NA |
| Lipemia | NA |
| Icterus | NA |
| Other | NA |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated (preferred) | 14 days |
| Ambient | 14 days | |
| Frozen | 14 days |
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Propoxyphene (Darvon) is an analgesic used for the treatment of mild-to-moderate pain that is not adequately relieved by aspirin. It is a congener of the narcotic methadone but is classified as a non-narcotic. It produces analgesia by binding to u-opioid receptors in the central nervous system (CNS).
Propoxyphene undergoes hepatic N-demethylation to produce a major metabolite, norpropoxyphene, which has one-fourth to one-half the pharmacologic activity of the parent drug. The serum half-lives of propoxyphene and norpropoxyphene are 8 to 24 hours and 20 to 50 hours, respectively. Rapid tissue binding of propoxyphene occurs, resulting in the immediate and almost complete disappearance from the bloodstream and relatively high concentrations in the brain, lung, liver, and kidney.
Toxic manifestations are similar to those produced by codeine and include respiratory and CNS depression, cardiac arrhythmias, pulmonary edema, hypotension, hallucinations, convulsions, and coma. Accidental or intentional ingestion of large amounts of propoxyphene may cause death.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
EMIT cutoff concentration: 300 ng/mL
Positives are reported with a quantitative GC-MS result.
GC/MS cutoff concentrations
Propoxyphene: <300 ng/mL
Norpropoxyphene: <300 ng/mL
Interpretation Provides information to assist in interpretation of the test results
A positive result derived by this testing indicates that the patient has used propoxyphene in the recent past.
Random urine collection results are not clinically definitive but the following values may be used as guidelines:
Propoxyphene:
1,000-5,000 ng/mL; typical for therapeutic dosages
>10,000 ng/mL; may indicate toxic blood concentration
>80,000 ng/mL; may indicate potentially lethal blood concentration
Norpropoxyphene:
2,000-20,000 ng/mL; typical for therapeutic dosages
>30,000 ng/mL; may indicate toxic blood concentration
>80,000 ng/mL; may indicate potentially lethal blood concentration
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Baselt RC: In Disposition of Toxic Drugs and Chemicals in Man, Fifth edition. Chemical Toxicology Institute, Foster City, CA 2000
Method Description Describes how the test is performed and provides a method-specific reference
Urine is preliminarily screened for the presence of propoxyphene by immunoassay technique. If the result is positive by this technique, the urine is subjected to gas chromatography-mass spectrometry analysis. If a compound chromatographs where a propoxyphene standard emerges with a mass spectrum consistent with that of a specific propoxyphene drug, the presence of that propoxyphene drug is confirmed. (Schwarzhoff RH, Hubster EC, Liserio MK: Enzyme immunoassay, kinetic microparticle immunoassay, radioimmunoassay, and fluorescence polarization immunoassay compared for drugs-of-abuse screening. Clin Chem 39:2137-2146, 1993; Foerster EH, Dempse J, Garriott JC: A gas chromatographic screening procedure for acid and neutral drugs in blood. J Anal Toxicol 3:87-91, 1979)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Screening performed Monday through Friday, Sunday
Gas Chromatography-Mass Spectrometry confirmation performed once a week
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
G0431-Screen
80299-Confirmation (if appropriate)
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| 11166 | Propoxyphene | 3545-1 |
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