Test ID: DAUCO
Drug of Abuse, Cocaine Screen with GC-MS Confirmation, Urine
NY State Approved 
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Detecting drug abuse involving cocaine
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| MSCO | Drug of Abuse, Cocaine Conf, U | Yes | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
If the cocaine screen is >149 ng/mL then cocaine confirmation is performed at an additional charge.
Method Name A short description of the method used to perform the test
DAUCO/505230: Enzyme-Multiplied Immunoassay Technique (EMIT)
MSCO/500369: Gas Chromatography-Mass Spectrometry (GC-MS)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
Cocaine Metabolite
DAU Cocaine Screen, Urine
Drugs of Abuse (Cocaine Screen), Urine
Crack (Cocaine)
Benzoylecgonine (Cocaine Metabolite)
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Container/Tube: Plastic, 10-mL urine tube (Supply T068)
Specimen Volume: 10 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | NA |
| Lipemia | NA |
| Icterus | NA |
| Other | NA |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated (preferred) | 14 days |
| Ambient | 14 days | |
| Frozen | 14 days |
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Cocaine, a central nervous system stimulant, is a drug of current health concern because of its proliferation among recreational drug abusers. Cocaine can be taken in a variety of ways. It can be inhaled, injected intravenously, or the base can be smoked (crack). Freebase and crack increase the potential for major toxicity. Increasingly, laboratory results are disputed or there are medical/legal overtones. Therefore, physicians are finding an increased need to confirm positive results before informing or confronting the patients.
Cocaine is almost completely metabolized by the liver, with only about 1% being excreted unchanged. The rate of excretion depends on the individual and the mode of administration. Benzoylecgonine is the major metabolite, but some is excreted as ecgonine methyl ester and ecgonine. Benzoylecgonine can be detected in urine within 4 hours following inhalation and can remain detectable for as long as 48 hours.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Negative
EMIT cutoff concentration: 150 ng/mL
Positives are reported with a quantitative GC-MS result.
Interpretation Provides information to assist in interpretation of the test results
The presence of cocaine, or its major metabolite, benzoylecgonine indicates use within the past 4 days.
Cocaine has a 6-hour half-life, so it will be present in urine for 1 day after last use.
Benzoylecgonine has a half-life of 12 hours, so it will be detected in urine up to 4 days after last use.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Baselt RC, Cravey RH: Disposition of Toxic Drugs and Chemicals in Man. Third edition. Chicago, Year Book Medical Publishers, 1989
Method Description Describes how the test is performed and provides a method-specific reference
The specimen is extracted using a solid phase extraction (SPE) procedure and then analyzed by gas chromatography/mass spectrometry (GC-MS) to identify and quantitate any cocaine and or benzoylecgonine present.(Armbruster DA, Schwarzhoff RH, Hubster EC, Liserio MK: Enzyme immunoassay, kinetic microparticle immunoassay, radioimmunoassay, and fluorescence polarization immunoassay compared for drugs-of-abuse screening. Clin Chem 1993;39:2137-2146; Ferrara SD, Tedeschi L, Frison G, et al: Drugs-of-abuse testing in urine: statistical approach and experimental comparison of immunochemical and chromatographic techniques. J Anal Toxicol 1994;18:278-291)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Friday, Sunday; Varies
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
80101-Screen
G0431-Screen–government payers (if appropriate)
82520-Confirmation (if appropriate)
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| 11161 | Cocaine Metabolite | 3394-4 |
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