Test ID: CDAG
Drug Screen, Prescription/OTC, Gastric
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Detection and identification of prescription or over-the-counter drugs frequently found in drug overdose or used with a suicidal intent.
This test is designed to provide, when possible, the identification of all drugs present.
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
See Prescription and Over-the-Counter (OTC) Drug Screens in Special Instructions.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
Gas-Liquid Chromatography (GLC)/Mass Spectroscopy
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
Amitriptyline (Elavil)
Amobarbital (Amytal)
Bupropion (Amfebutamone, Wellbutrin, Zyban)
Butabarbital (Butisol)
Butalbital (Fiorinal)
Caffeine
Carbamazepine (Tegretol)
Carisoprodol (Soma)
Chlordiazepoxide (Librium)
Chlorpheniramine (Chlor-Trimeton, Efidac, Teldrin)
Chlorproamide (Diabinese)
Citalopram (Celexa)
Clomipramine (Anafranil)
Clozapine (Clozaril)
Codeine
Cylclobenzaprine (Flexeril)
Desipramine (Norpramin)
Dextromethorphan
Diazepam (Valium)
Diltiazem (Cardizem)
Diphenhydramine (Benadryl)
Doxepin (Sinequan)
Doxylamine (Unisom)
EDDP (methadone metabolite)
Ethosuximide (Zarontin)
Etomidate (Amidate)
Felbamate (Felbatol) Performed at Mayo New England
Fentanyl (Actiq, Fentora)
Fluoxetine (Prozac)
Gemfibrozil (Lopid)
Gemonil (Metharbital)
Glutethimide (Doriden)
Humibid (Guaifenesin)
Humibid LA (Guaifenesin)
Hydroxyzine (Atarax)
Ibuprofen (Advil, Motrin, Nuprin)
Imipramine (Tofranil)
Lamotrigine (Lamictal)
Lidocaine (Xylocaine)
Lorazepam (Ativan)
Mephobarbital (Mebaral)
Meprobamate (Miltown)
Metaxalone (Skelaxin)
Methadone (Dolophine)
Methocarbamol (Robaxin)
Methsuximide (Celontin)
Methylphenidate (Ritalin)
Metronidazole (Flagyl)
Midazolam (Versed)
Mirtazapine (Remeron)
Naproxen (Naprosyn)
Nordizepam (Tranxene)
Normethsuximide
Norpropoxyphene (Metabolite of Propoxyphene) (Darvon)
Nortriptyline (Pamelor)
Oxcarbazepine Metabolite (MHC)
Oxcarbazepine Metabolite (MHD)
Paroxetine (Paxil)
Pentazocine (Talwin)
Pentobarbital (Nembutal)
Pentoxifylline (Pentopak, Pentoxil, Trental)
Phencyclidine (PCP)
Phenobarbital
Phenytoin (Dilantin)
Primidone (Mysoline)
Promethazine (Phenergan)
Propofol (Diprivan)
Propoxyphene (Darvon)
Quetiapine (Seroquel)
Quinidine (Quinidex)
Salicylate
Secobarbital (Seconal)
Sertraline (Zoloft)
Temazepam (Restoril)
Theophylline (Aerolate)
Thiopental (Pentothal)
Thioridazine (Mellaril)
Ticlopidine (Ticlid)
Topiramate (Topamax)
Tramadol (Ultram)
Trazodone (Desyrel)
Trimipramine (Surmontil)
Valproic Acid (Depakote)
Venlafaxine (Effexor)
Verapamil (Calan)
Zolpidem (Ambien)
Hydrocodone (Acetaminophen, Ibuprofen)
Guaifenesin (Fenesin, Humidid, Humibid LA, Mucinex, Organidin NR, Robitussin)
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Specimen Type: Gastric content
Container/Tube: Sterile container
Specimen Volume: 5 mL
Collection Instructions: No preservative.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | NA |
| Lipemia | NA |
| Icterus | NA |
| Other | NA |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| Varies | Ambient (preferred) | 14 days |
| Frozen | 14 days | |
| Refrigerated | 14 days |
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
This test looks for a broad spectrum of prescription and over-the-counter (OTC) drugs. It is designed to detect drugs that have toxic effects, as well as known antidotes or active therapies that a clinician can initiate to treat the toxic effect. The test is intended to help physicians manage an apparent overdose or intoxicated patient, to determine if a specific set of symptoms might be due to the presence of drugs, or to evaluate a patient who might be abusing these drugs intermittently. The test is not designed to screen for intermittent use of illicit drugs.
Drugs of toxic significance that are not detected by this test are: digoxin, lithium, and many drugs of abuse/illicit drugs, some benzodiazepines, and some opiates.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
None detected
Interpretation Provides information to assist in interpretation of the test results
The drugs that can be detected by this test are listed in Prescription and Over-the-Counter (OTC) Drug Screens Table 2 in Special Instructions.
Positive results are definitive.
Drugs of toxic significance that are not detected by this test include digoxin, lithium, many drugs of abuse/illicit drugs, some benzodiazepines, and some opiates. For these drugs, see Mayo Medical Laboratories' drug abuse surveys or drug screens or individual tests.
A detailed discussion of each drug detected is beyond the scope of this text. Each report will indicate the drugs identified. If a clinical interpretation is required, please request a Drug/Toxicology Lab consult (Mayo Clinic patients) or contact Mayo Laboratory Inquiry (Mayo Medical Laboratories clients).
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Not intended for use in employment-related testing.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
1. Tietz Textbook of Clinical Chemistry. 3rd edition. Edited by CA Burtis, ER Ashwood. Philadelphia, WB Saunders Company 1999, pp 913-917
2. Disposition of Toxic Drugs and Chemicals in Man. 5th edition. Edited by RC Baselt, RH Cravey. Foster City, CA, Chemical Toxicology Institute, 2000
Method Description Describes how the test is performed and provides a method-specific reference
Significant concentrations of many drugs can be extracted from aqueous weakly acidic (pH 4.0) solutions into a mixed organic phase of 80% chloroform, 20% ethyl acetate. After separation of the organic phase from the aqueous phase, the organic phase is dehydrated with anhydrous sodium sulfate and then evaporated. The residue containing concentrated drugs is redissolved in 100 L of pyridine/hexane, and an aliquot is subjected to gas chromatographic separation. Drugs present are identified by chromatographic retention time (gas chromatography) compared against a mixture of drug standards, and by structural analysis performed by mass spectrometry (GC/MS). (Foerster EH, Dempsey J, Garriott JC: A gas chromatographic screening procedure for acid and neutral drugs in blood. J Anal Toxicol 1979;3:87-91 as modified to incorporate some alkaline drugs by LE Ebnet and TP Moyer, Mayo Clinic)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Friday, Sunday
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
80100 -Drug screen, qualitative, each procedure
G0431-Drug screen, qualitative, each specimen-government payers (if appropriate)
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| 500055 | Drugs detected: | 12287-9 |
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