Renal Biopsy, Electron Microscopy
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Evaluation of patients with undiagnosed kidney disease
Following the course of therapy or progression of disease
Diagnosing disease with only electron microscopic alterations
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
88501 Renal Pathology Consultation and 8331 Renal Biopsy, Light Microscopy must be ordered with this test and will be charged separately.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Renal Bx, Electron Microscopy
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
This test is not a stand-alone, orderable test, but must be accompanied by 88501 Renal Pathology Consultation and 8331 Renal Biopsy, Light Microscopy.
Container/Tube: Renal Biopsy Kit (Supply T231)
Specimen Volume: Entire specimen
Collection Instructions: Collect specimens according to the instructions in Renal Biopsy-Procedures of Handling Tissue for Light Microscopy, Immunohistology, and Electron Microscopy in Special Instructions.
1. Renal Biopsy Patient Information Sheet in Special Instructions
2. If not ordering electronically, submit a Pathology/Cytology Request Form (Supply T246) with the specimen.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Kidney biopsy has proven of value in the clinical evaluation and management of patients with undiagnosed kidney disease. The clinical setting may include acute renal failure, nephrotic syndrome, asymptomatic proteinuria and hematuria. Kidney diseases in the setting of a systemic disease are often diagnosed on kidney biopsy.
Biopsy of the transplanted kidney is important in the determination of the presence of acute rejection, infection, or recurrent disease.
Optimal interpretaion of a kidney biopsy requires integration of clinical and laboratory results with light microscopic, immunofluorescent histology, and electron microscopy findings.
Electron microscopy is required for the diagosis of Alport syndrome, dense deposit disease, thin glomeular basement membrane nephropathy, and fibrillary glomerulonephritis; and is helpful in evaluating secondary causes of glomerulonephritis such as lupus nephritis.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
An interpretive report will be provided.
A written report is issued along with appropriate annotated electron microscopic photomicrographs.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Accurate and timely interpretation of a kidney biopsy requires integration of light microscopic, immunofluorescent histology, and electron microscopic findings with clinical and laboratory data.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Tisher CC: Clinical indication for kidney biopsy. In Renal Pathology: with Clinical and Functional Correlations. Vol. II. 2nd edition. Edited by CC Tisher, BM Brenner. Philadelphia, JB Lippincott Book Company, 1989, pp 2-10
Method Description Describes how the test is performed and provides a method-specific reference
Standard methods of tissue fixation and preparation are utilized. Appropriate fixatives and instructions are supplied. (Velosa JA, Holley KE: Pathology and immunopathology of renal diseases. In Renal Function Tests: Clinical Laboratory Procedures and Disorders. Edited by CG Duarte. Boston, MA, Little, Brown, and Company, 1980, pp 360-361)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Friday; Continuously, 7 a.m.-10:30 a.m.
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
This test uses a standard method. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
|Result ID||Reporting Name||LOINC Code|
|19334||Renal Bx, Electron Microscopy||In Process|