Glucose, Spinal Fluid
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Investigating possible central nervous system infection
Photometric, Glucose Oxidase/Peroxidase (VITROS Dry Slide)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Collection Container/Tube: Sterile vial
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge to remove any cellular material.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
|CSF||Frozen (preferred)||30 days|
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Cerebrospinal fluid (CSF) is secreted by the choroid plexuses, around the cerebral vessels, and along the walls of the ventricles of the brain, filling the ventricles and cisternae and bathing the spinal cord. CSF is reabsorbed into the blood through the arachnoid villi. CSF turnover is rapid, exchanging about 4 times per day.
CSF glucose levels may be decreased due to consumption by microorganisms, impaired glucose transport, or increased glycolysis. Elevated CSF glucose levels are consistent with hyperglycemia.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Spinal fluid glucose concentration should be approximately 60% of the plasma/serum concentration and should be compared with concurrently measured plasma/serum glucose for adequate clinical interpretation.
Cerebrospinal fluid (CSF) glucose levels may be decreased in any central nervous system infection, although levels are typically normal in viral meningitis, low in bacterial meningitis, and may be normal or low in fungal meningitis.
CSF glucose levels are normally about 60% of blood glucose levels.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Handle specimens in stoppered containers to avoid contamination and evaporation.
Cerebrospinal fluid specimens should be processed without delay; they may contain cellular constituents, as well as organisms, that lower the concentration of glucose with time.
Processed specimens can be stored at 2 to 8 degrees C for up to 7 days.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Tietz Textbook of Clinical Chemistry. 4th edition. Edited by CA Burtis, ER Ashwood, D Burns. Philadelphia, WB Saunders Company, 2006 pp 837-891
Method Description Describes how the test is performed and provides a method-specific reference
Patient specimen is deposited on the slide where the spreading layer promotes the uniform distribution of the specimen and permits an even penetration of solute molecules into the underlying reagent layer. The oxidation of specimen glucose is catalyzed by glucose oxidase to form hydrogen peroxide and gluconate. The reaction is followed by an oxidative coupling catalyzed by peroxidase in the presence of dye precursors to produce a dye. The intensity of the dye is measured by reflected light.
Each mole of glucose oxidized results in 0.5 mole of dye, assuming quantitative conversions. The intensity of the dye is measured by reflected light at 540 nm and concentration is reported in milligrams per deciliter. (Package insert: Ortho-Clinical Diagnostics. United Kingdom, 2004)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Sunday; Continuously
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Same day/1 day
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
|Result ID||Reporting Name||LOINC Code|