17073:
Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Screen

CPT Code Information Current Value

81301-Microsatellite instability analysis (eg, hereditary non-polyposis colorectal cancer, Lynch syndrome) of markers for mismatch repair deficiency (eg, BAT25, BAT26), includes comparison of neoplastic and normal tissue, if performed.

88381-Microdissection, manual

MLH-1, Immunostain

88342 (if appropriate)

MSH-2, Immunostain

88342 (if appropriate)

MSH-6, Immunostain

88342 (if appropriate)

PMS-2, Immunostain

88342 (if appropriate)

CPT Code Information Value Prior to 12/14/2012 10:02am

81301-Microsatellite instability analysis (eg, hereditary non-polyposis colorectal cancer, Lynch syndrome) of markers for mismatch repair deficiency (eg, BAT25, BAT26), includes comparison of neoplastic and normal tissue, if performed.

Slide Review, Molecular Genetics

88387

MLH-1, Immunostain

88342 (if appropriate)

MSH-2, Immunostain

88342 (if appropriate)

MSH-6, Immunostain

88342 (if appropriate)

PMS-2, Immunostain

88342 (if appropriate)

For nonparticipating payers:

Microsatellite Instability (MSI), Tumor

83890 x 2-Molecular isolation or extraction

83900 x 2-Amplification, target, multiplex, first 2 nucleic acid sequences

83901 x 6-Amplification, target, multiplex, each additional nucleic acid sequences beyond 2

83909 x 2-Separation and identification by high-resolution technique

83912-Interpretation and report

Slide Review, Molecular Genetics

88387

MLH-1, Immunostain

88342 (if appropriate)

MSH-2, Immunostain

88342 (if appropriate)

MSH-6, Immunostain

88342 (if appropriate)

PMS-2, Immunostain

88342 (if appropriate)