ARST - Overview: Arylsulfatase A, Fibroblasts

Test Catalog

Test ID: ARST    
Arylsulfatase A, Fibroblasts

Useful For Suggests clinical disorders or settings where the test may be helpful

Detection of metachromatic leukodystrophy

Genetics Test Information Provides information that may help with selection of the correct test or proper submission of the test request

First order ARSAW / Arylsulfatase A, Leukocytes and ARSU / Arylsulfatase A, 24 Hour, Urine.


Metachromatic leukodystrophy (MLD) presents with progressive neurologic changes and leukodystrophy with variable age of onset.


Arylsulfatase A enzyme levels are decreased in individuals with MLD, and excessive amounts of sulfatides are present in urine.


Decreased arylsulfatase A enzyme levels can be seen in unaffected individuals who have a pseudodeficiency of arylsulfatase A.

Additional Tests Lists test(s) that are always performed, at an additional charge, with the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
CRYOBCryopreserve for Biochem StudiesNoYes
FIBRFibroblast CultureYesYes

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

When this test is ordered, a fibroblast culture and cryopreservation for biochemical studies will always be performed at an additional charge. However, for multiple lysosomal enzyme assays on a patient utilizing fibroblast culture, only 1 culture is required regardless of the number of enzyme assays ordered. If viable cells are not obtained within 10 days, client will be notified.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

ARST: Colorimetric Enzyme Assay

FIBR: Cultivated from Biopsy as Monolayer

CRYOB: Fibroblast Subculture Followed by Cryopreservation and Storage

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Arylsulfatase A, Fibroblasts

Aliases Lists additional common names for a test, as an aid in searching

ARSA deficiency
Arylsulfatase A deficiency
Metachromatic Leukodystrophy