|Values are valid only on day of printing.|
Diagnosis of adult individuals suspected of having transthyretin-associated familial amyloidosis
Mass spectrometry to evaluate transthyretin (TTR) protein structure is performed first. In all cases demonstrating a structural change, the TTR gene will be further analyzed by DNA sequence analysis. If no alterations are detected, subsequent gene analysis will not be performed unless a request for ATTRZ / TTR Gene, Full Gene Analysis is submitted by the ordering physician or client.
|Test ID||Reporting Name||Available Separately||Always Performed|
|ATTRZ||TTR Gene, Full Gene Analysis||Yes||No|
If familial amyloidosis by liquid chromatography-mass spectrometry is abnormal, DNA sequence will be performed and charged separately.
See Amyloidosis (Familial) Test Algorithm in Special Instructions.
Liquid Chromatography-Mass Spectrometry (LC-MS)