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Test Catalog

Test ID: MLH1H    
MLH1 Hypermethylation Analysis, Tumor

Specimen Type Describes the specimen type needed for testing


Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.

This test is only performed on colon or endometrial tumors with confirmed loss of MLH1 protein expression.


Pathology report must accompany specimen in order for testing to be performed.


Specimen Type: Tissue block or slide

Collection Instructions:                 

1. Submit formalin-fixed, paraffin-embedded tissue block (preferred) or 1 slide stained with hematoxylin and eosin and 10 unstained, nonbaked slides (5-micron thick sections) of the tumor tissue.

2. Sections should contain tumor tissue.


1. Molecular Genetics-Inherited Cancer Syndromes Patient Information Sheet (Supply T519) in Special Instructions

2. If not ordering electronically, submit a Molecular Genetics Request Form (Supply T245) with the specimen.

Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected









Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.

Specimen TypeTemperatureTime
VariesAmbient (preferred)