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Test ID: MGLES    
Myasthenia Gravis (MG)/Lambert-Eaton Syndrome (LES) Evaluation

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

If acetylcholine receptor (AChR) modulating antibodies are > or =90% and striational antibodies are > or =1:120, then AChR ganglionic neuronal antibody and CRMP-5-IgG Western blot will be performed at an additional charge.

 

This evaluation is recommended for patients presenting with an acquired defect of neuromuscular transmission in whom the differential diagnosis includes Lambert-Eaton syndrome (LES). It is not recommended for patients with a past history of, or risk factors for, lung cancer and/or concurrent neurological symptoms/signs not attributable to LES; for those situations, order PAVAL / Paraneoplastic Autoantibody Evaluation, Serum. Testing for a newly recognized alternative antibody of myasthenia gravis (MG) (muscle-specific receptor tyrosine kinase) is indicated when all tests are negative.

 

See Myasthenia Gravis/Lambert Eaton Syndrome Diagnostic Algorithm in Special Instructions.

Specimen Type Describes the specimen type needed for testing

Serum

Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.

Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 3 mL

Additional Information: Patient should have no general anesthetic or muscle-relaxant drugs in the previous 24 hours.

Forms: If not ordering electronically, complete, print, and send a Neurology Test Request Form-General (T732) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/neurology-request-form.pdf)

Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.

2 mL

Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross reject

Icterus

Mild OK; Gross reject

Other

NA

 

Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.

Specimen TypeTemperatureTime
SerumRefrigerated (preferred)28 days
 Frozen 28 days
 Ambient 72 hours

Key