PCPRO - Specimen: Plasma Cell DNA Content and Proliferation, Bone Marrow

Test Catalog

Test Name

Test ID: PCPRO    
Plasma Cell DNA Content and Proliferation, Bone Marrow

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

When this test is ordered, flow cytometry interpretation will always be performed at an additional charge.

 

See Laboratory Screening Tests for Suspected Multiple Myeloma in Special Instructions.

Specimen Type Describes the specimen type needed for testing

Bone Marrow

Advisory Information

This test should be ordered at diagnosis of Multiple Myeloma. However, if wanting MPCPD / mSMART, Plasma Cell Proliferative Disorder (PCPD), FISH to be performed at Mayo, order MSMRT / Mayo Algorithmic Approach for Stratification of Myeloma and Risk-Adapted Therapy Report. The Laboratory Screening Tests for Suspected Multiple Myeloma algorithm will allow plasma cell FISH to be reflexed based on the PCPRO flow results.

Necessary Information

1. Include patient's disease state (untreated, treated, monoclonal gammopathy of undetermined significance, stable).

2. Indicate if patient is on anti-CD38 therapy.

Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.

Specimen Type: Redirected bone marrow

Preferred: Yellow top (ACD)

Acceptable: EDTA or heparin

Specimen Volume: 4 mL

Specimen Stability Information: <72 hours

Forms

If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request Form (T726) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/hematopathology-request-form.pdf)

Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.

2 mL

Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected

Hemolysis

Mild OK; Gross reject

Lipemia

NA

Icterus

NA

Other

Fully clotted or frozen specimen

Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.

Specimen TypeTemperatureTime
Bone MarrowAmbient (preferred)
 Refrigerated