Encephalopathy, Autoimmune Evaluation, Serum
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
If indirect immunofluorescence assay (IFA) suggests ANN1S, ANN2S, ANN3S, PCAB2, PCATR, AMPHS, CRMS, or AGN1S is indeterminate, then paraneoplastic autoantibody Western blot is performed at an additional charge.
If client requests, or if IFA patterns suggests CRMP-5-IgG, then CRMP-5-IgG Western blot is performed at an additional charge.
If IFA patterns suggest amphiphysin antibody, then amphiphysin Western blot is performed at an additional charge.
If IFA pattern suggest NMO/AQP4-IgG, then NMO/AQP4-IgG FACS is performed at an additional charge.
If NMO/AQP4-IgG FACS screen assay is positive, then NMO/AQP4-IgG FACS titration assay is performed at an additional charge.
If IFA pattern suggest NMDA-R antibody and NMDA-R antibody CBA is positive, then NMDA-R titer is performed at an additional charge.
If IFA pattern suggest AMPA-R antibody and AMPA-R antibody CBA is positive, then AMPA-R titer is performed at an additional charge.
If IFA pattern suggest GABA-B-R antibody and GABA-B-R antibody CBA is positive, then GABA-B-R titer is performed at an additional charge.
Native neuronal antigens: performed to confirm neuronal nuclear and cytoplasmic antibody specificities when IF screening is uninterpretable.
Recombinant human collapsin response-mediator protein 5: performed to confirm CRMP-5-IgG when IF screening is uninterpretable. Also performed for more sensitive detection of CRMP-5-IgG.
Recombinant human amphiphysin: performed to confirm amphiphysin when IF screening is uninterpretable. Also performed for more sensitive detection of amphiphysin.
See Encephalopathy Autoimmune Evaluation Algorithm, Serum in Special Instructions
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Preferred: Red top
Acceptable: Serum gel
Specimen Volume: 4 mL
Additional Information: Include relevant clinical information, name, phone number, mailing address, and e-mail address (if applicable) of ordering physician.
Forms: If not ordering electronically, complete, print, and send a Neurology Test Request Form-General (T732) with the specimen (http://www.mayomedicallaboratories.com/media/customer-service/forms/neurology-request-form.pdf)
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Mild OK; Gross reject
Mild OK; Gross reject
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
|Serum||Refrigerated (preferred)||28 days|