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When only a brain is submitted, this test will be performed and charged.
When both a brain and spinal cord are submitted, 65094 / Central Nervous System with Spinal Cord Consultation, Autopsy (Bill Only) will be performed and 5368 / Central Nervous System Consultation, Autopsy will be credited.
It is imperative that detailed clinical information and, when possible, operative notes and radiographs accompany the specimen. Hematoxylin-and-eosin stained sections are also acceptable, but must be accompanied by paraffin blocks and/or remaining wet tissue.
1. If not ordering electronically, complete, print, and send a Pathology Test Request Form (T246) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/pathology-request-form.pdf).
2. Submitting Non-Protocol Autopsy Brain/Spinal Cord for Examination or Submitting Brain for Neuropathologic Examination-Cases Suspected of Creutzfeldt-Jakob Disease (CJD) in Special Instructions.
Upon completion of consultation, the brain tissue will be stored indefinitely in the Mayo Clinic Tissue Registry. The Mayo Clinic policy precludes our evaluation of cases under litigation that involve non-Mayo Clinic patients.
Supplies: Central Nervous System Consult Kit (T633)
Specimen Type: Complete brain (and spinal cord when indicated)
Container/Tube: Container with 10% formalin and plastic bag
Specimen Volume: Entire brain
1. Divide brain in half.
2. Place half the brain in 10% formalin if non-CJD, and 15% formalin for suspected cases of CJD, suspended by a thread under the basilar artery and fixed for 7 to 10 days.
3. Place other half of the brain into a plastic bag labeled with identifying information (ie, patient name, date of birth, autopsy number, and date of collection). Freeze and store in a -70 degrees C freezer.
4. Ship specimen using the Central Nervous System Consult Kit (T633).
Specimen Type: Tissue
Sources: Brain (and spinal cord when indicated)
Container/Tube: Plastic container
Specimen Volume: 1 cm(3) cube
1. Take a small (1 cm) cube of brain from 1 of the frontal lobes (typically, right inferior frontal).
2. Wrap in aluminum foil and place in plastic container.
3. Label container with identifying information (ie, patient name, date of birth, autopsy number, and date of collection).
4. Freeze and store in a -70 degrees C freezer.
5. Place the remaining brain in 10% formalin if non-CJD, and 15% formalin for suspected cases of CJD, suspended by a thread under the basilar artery and fixed for 7 to 10 days.
6. Ship specimen using the Central Nervous System Consult Kit (T633).
Note: No specimen should be rejected. If specimen not received at appropriate temperature, include note to laboratory. If questions, contact laboratory.