5368 - Specimen: Central Nervous System Consultation, Autopsy

Test Catalog

Test Name

Test ID: 5368    
Central Nervous System Consultation, Autopsy

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

When only a brain is submitted, this test will be performed and charged.

When both a brain and spinal cord are submitted, 65094 / Central Nervous System with Spinal Cord Consultation, Autopsy (Bill Only) will be performed and this test (5368) will be credited.

Specimen Type Describes the specimen type needed for testing


Advisory Information

Cases under litigation will not be accepted.

Shipping Instructions

Ship specimen using the Central Nervous System Consult Kit (T633).

Necessary Information

It is imperative that detailed clinical information and, when possible, operative notes and radiographs accompany the specimen.


In cases submitted as part of a specifically identified research protocol, contact 507-284-3887 for further guidance.

Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.

Hematoxylin-and-eosin stained sections are also acceptable, but must be accompanied by paraffin blocks and/or remaining wet tissue.


Supplies: Central Nervous System Consult Kit (T633)

Sources: Brain (and spinal cord when indicated)

Container/Tube: Plastic container

Specimen Volume: 1 cm(3) cube

Collection Instructions:

1. Take a small, 1 cm(3) cube of brain tissue from one of the frontal lobes (typically, right inferior frontal).

2. Wrap in aluminum foil and place in plastic container.

3. Label container with identifying information (ie, patient name, date of birth, autopsy number, and date of collection).

4. Freeze and store in a -70 degrees C freezer.

5. Place the remaining brain in 10% formalin if non- Creutzfeldt-Jakob Disease (CJD), and 15% formalin for suspected cases of CJD, suspended by a thread under the basilar artery and fixed for 7 to 10 days.

Additional Information: Upon completion of consultation, the brain tissue will be stored indefinitely in the Mayo Clinic Tissue Registry. The Mayo Clinic policy precludes our evaluation of cases under litigation that involve non-Mayo Clinic patients.


1. If not ordering electronically, complete, print, and send a Pathology Test Request Form (T246) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/pathology-request-form.pdf).

2. Submitting Non-Protocol Autopsy Brain/Spinal Cord for Examination or Submitting Brain for Neuropathologic Examination-Cases Suspected of Creutzfeldt-Jakob Disease (CJD) in Special Instructions.

Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.

Entire collection

Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected

No specimen should be rejected.

Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.

Specimen TypeTemperatureTime
TissueAmbient (preferred)
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