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Co-receptor tropism is defined as an interaction of a virus with
a specific co-receptor on the target cell. To gain entry into
CD4+ cells, HIV must bind to the cell surface CD4 receptor and
to one of two co-receptors, CCR5 or CXCR4.
Trofile is a cell-based approach to determine a patientâ€™s
HIV co-receptor tropism (or â€œTropotypeâ„¢). Trofile uses the
complete gp160 coding region of the HIV-1 envelope protein
ensuring that all of the determinants of tropism are tested.
CLIA validation experiments demonstrate that Trofile is 100%
sensitive at detecting 0.3% CXCR4-using minor variants.
This class of drugs binds to CCR5 and blocks CCR5-mediated
HIV entry into host cells. Trofile is used to determine whether
a CCR5 antagonist may be an appropriate drug for a patient.
Several clinical trails on CCR5 antagonists have demonstrated
the positive and negative predictive value of Trofile in clinical
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