Cold Agglutinin Titer, Serum
Method Description Describes how the test is performed and provides a method-specific reference
A screen will be performed on all specimens first to identify most of those with titer values in the normal range. If the screen is negative, no titration will be performed and the screen will be reported as negative. If the screen is positive, a titer will be performed and the screen will be reported as positive.
The titer is determined by making serial doubling dilutions of the patient's serum in 0.9% saline. Group O indicator red cells are added and the serum-cell mixture is then incubated 20 minutes at 0 to 5 degrees C, and the titer end point range is determined.(Ellenhorn MJ, Weiner D: Variables in determination of cold hemagglutinins. Am J Clin Pathol 1953;23:1031-1039)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Friday, Sunday; Continuously
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
See Individual Unit Codes
Performing Laboratory Location The location of the laboratory that performs the test