Manganese (Mn) is analyzed using an inductively coupled plasma-mass spectrometer with universal cell technology (UCT) operated in dynamic reaction cell (DRC) mode. Aqueous acidic calibrating standards, reagent blanks, quality control specimen, and patient specimens are diluted with aqueous acidic diluent containing internal standard. In turn, the dilutions are aspirated by a pneumatic high-pressure nebulizer driven by argon gas. The nebulized solutions suspended in the carrier argon gas stream are injected into a high temperature (6800 K) argon gas discharge (plasma). The plasma decomposes, atomizes, and ionizes the nebulized particles. All atoms, molecules, and ions formed in the discharge are extracted via a platinum orifice and enter the quadrapole ion deflector (QID) where only the ions are bent at a 90 angle and pass into a quadrapole with UCT. The quadrapole cell is filled with ammonia (NH3), which chemically reacts with the ion beam to remove polyatomic interferences and focus the beam into a quadrapole mass spectrometer. Mn ions are separated from the remaining concomitants by the quadrapole mass spectrometer allowing only Mn ions to collide with the instrument detector to produce a signal proportional to the bulk concentration of Mn in the sample and calculated by the instrument based upon a ratio with the internal standard gallium.