CUT - Performance: Copper, Liver Tissue

Test Catalog

Test ID: CUT    
Copper, Liver Tissue

Method Description Describes how the test is performed and provides a method-specific reference

After digestion of the liver tissue with nitric acid and hydrogen peroxide, the digest is diluted and tissue copper concentration is determined using an inductively coupled plasma-mass spectrometer in dynamic reaction cell mode. Calibrating standards and blanks are diluted with an aqueous acidic diluent containing internal standard(s). Quality control specimens and patient samples are diluted in an identical manner. In turn, all diluted blanks, calibrating standards, quality control specimens, and patient specimens are aspirated into a pneumatic nebulizer and the resulting aerosol directed to the hot plasma discharge by a flow of argon. In the annular plasma the aerosol is vaporized, atomized, then ionized. The ionized gases plus neutral species formed in the annular plasma space are aspirated from the plasma through an orifice into a quadrupole mass spectrometer. The mass range from 1 to 263 amu is rapidly scanned multiple times and ion counts tabulated for each mass of interest. Instrument response is defined by the linear relationship of analyte concentration vs. ion count ratio (analyte ion count/internal standard ion count). Analyte concentrations are derived by reading the ion count ratio for each mass of interest and determining the concentration from the response line. Results are reported in mcg copper/g dry weight of tissue.(Bush VJ, Moyer TP, Batts KP, Parisi JE: Essential and toxic element concentrations in fresh and formalin-fixed human autopsy tissues. Clin Chem 1995:41[2];284-294; Hanley MM: Copper and iron liver tissue analysis: a comprehensive platform comparison [Abstract 1600-7P]. PittCon 2008, New Orleans, Louisiana, March 2-7, 2008)

PDF Report Indicates whether the report includes an additional document with charts, images or other enriched information


Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.

Monday, Wednesday, Friday; 11 a.m.

Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.

2 days

Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result

5 days

Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

Fresh tissue: 1 month Block: Returned to client after 3 days

Performing Laboratory Location The location of the laboratory that performs the test