HYOX - Performance: Hyperoxaluria Panel, Urine

Test Catalog

Test ID: HYOX    
Hyperoxaluria Panel, Urine

Method Description Describes how the test is performed and provides a method-specific reference

Urine samples corresponding to 0.25 mg of creatinine (not to exceed 1 mL of urine) are oximated by reaction with methoxyamine hydrochloride to stabilize one of the target analytes, 4-hydroxy-2-oxoglutaric (HOG). The urine is then acidified and extracted with 4:1 ethyl acetate:isopropanol. After evaporation, the dry residue is silylated with 80:20 BSTFA/1%TMCS:pyridine and analyzed by capillary gas chromatography/mass spectrometry (GC/MS). In the context of hyperoxaluria, per se a non-specific finding, the detection of elevated excretions of urinary glycolate and glycerate allows the differential diagnosis between hyperoxaluria type 1 and type 2. Increased concentrations of oxalate and glycolate indicate type1 hyperoxaluria. Increased concentrations of oxalate and glycerate indicate type 2 hyperoxaluria. Increased concentration of HOG indicates type 3 hyperoxaluria, or carrier status for this disease. Increased concentrations of oxalate with normal concentrations of glycolate, glycerate, and HOG indicate secondary hyperoxaluria.(Unpublished Mayo method)

PDF Report Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.

Varies; Batched 2 times per month; 8 a.m.

Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.

14 days

Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

2 months

Performing Laboratory Location The location of the laboratory that performs the test

Rochester