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Test ID: ADMA    
Asymmetric Dimethylarginine, Plasma

Method Description Describes how the test is performed and provides a method-specific reference

Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and arginine (Arg) are separated and quantified by liquid chromatography-tandem mass spectrometry. C13-labeled ADMA and Arg internal standards (IS) are added to the samples and protein is precipitated using acetonitrile. A Cyclone MCX cation exchange turboflow column is used for sample clean-up, while a Waters Sunfire Silica analytical column is used for separation of ADMA, SDMA and Arg.  From this column, the sample is transferred to an API 5000 tandem mass spectrometer (MS/MS) for instrumental analysis. The ratios of the extracted peak areas of ADMA and SDMA to C13(5)-ADMA and of Arg to C13(6)-Arg are used to calculate the concentration of the respective analytes present. SDMA is not reported, since it is analyzed only to ensure continuing separation from ADMA.(Unpublished Mayo method)

PDF Report Indicates whether the report includes an additional document with charts, images or other enriched information


Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.

Wednesday; 11 a.m.

Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.

2 days

Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result

9 days

Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

7 days

Performing Laboratory Location The location of the laboratory that performs the test