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C1q complement activity is measured by mixing patient serum with
a C1q-deficient serum. The lytic activity of the serum mixture is
tested against sensitized, labeled liposomes. If lysis occurs, the
patient serum must be the source of the C1q. The target liposomes
are a commercial reagent (WAKO total complement CH[50]), and
the assay is performed on a Hitachi 911. (Unpublished Mayo
information Yamamoto S, Kubotsu K, Masaaki K, et al: Automated
homogeneous liposome-based assay system for total complement
activity. Clin Chem 1995;41:586-590)

