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Unit Code 81835:
C2 Complement, Functional, Serum

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Method Description

C2 complement activity is measured by mixing patient serum with a

C2-deficient serum.  The lytic activity of the serum mixture is tested

against sensitized, labeled liposomes.  If lysis occurs, the patient serum

must be the source of the C2.  The target liposomes are a commercial

reagent (WAKO total complement CH[50]), and the assay is performed

on a Hitachi 911.  If an abnormally low C2 result is obtained, the

laboratory will confirm the deficiency with a quantitative C2 antigen

assay (radial immunodiffusion) and also measure C3 and C4 levels to

help interpret the abnormal C2 result.  (Unpublished Mayo information)

Performing Laboratory Location

Rochester

Key