Unit Code 81252:
Zygosity Testing (Multiple Births)
Method Description
PCR-based assays that recognize highly variable regions of human
DNA are used to provide a genotype for multiples and their parents.
The number of markers (microsatellites) used is determined on a case-
by-case basis to ensure >99.9% predictive value. Generally, between
6 and 11 markers are used. Calculation of zygosity probability is made using
Bayesian analysis. (Neitzel H, Digweed M, Nurnberg P, et al: Routine
applications of DNA fingerprinting with the oligonucleotide probe [CAC]5/
[GTG]5. Clin Genet 1991;39(2):97-103)
Performing Laboratory Location
Rochester
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