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Unit Code 80339:
Haloperidol, Serum

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Method Description

Haloperidol, reduced haloperidol (its major metabolite), and the internal

standard (haloperidol d4) are extracted from alkaline serum into 5%

isopropyl alcohol in hexane.  The organic fraction is dried and reconstituted

with methanol.  Analysis is performed on an isocratic liquid chromatography

(LC) system with tandem mass spectrometry (MS/MS) detection.  (Hempenius J,

Steenvoorden RJ, Lagerwerf FM, et al:  "High throughput” solid-phase

extraction technology and turbo ionspray LC-MS-MS applied to the deter-

mination of haloperidol in human plasma. J Pharmaceut Biomed Anal

1999;20:889-898)

Performing Laboratory Location

Rochester

Key