ADAMTS13 Activity and Inhibitor Profile
Method Description Describes how the test is performed and provides a method-specific reference
The ADAMTS13 activity is measured by a fluorescence resonance energy transfer (FRET)-based assay using a 73 amino-acid peptide (FRETS-VWF73) of von Willebrand factor (VWF) as substrate. The inhibitor screen and titer assay are performed by using mixing studies that are similar to the Bethesda assay. One inhibitor (Bethesda) unit is defined as the concentration of an inhibitor that is able to reduce ADAMTS13 activity of normal pooled plasma by 50%.(Kokame K, Nobe Y, Kokubo Y, et al: FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay. Br J Haematol 2005 Apr;129:93-100)
PDF Report Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Sunday; Varies
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
ADAMTS13 Activity Assay: 24 hours/ADAMTS13 Inhibitor Assay: 1-3 days/ADAMTS13 Bethesda Titer: 1-3 days
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test