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Unit Code 28380:
Parathyroid Hormone (PTH), with Minerals, Serum

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Method Description

The Roche COBAS assay for determining intact PTH employs

a sandwich test principle in which a biotinylated monoclonal

antibody reacts with the N-terminal fragment (1-37) and a

monoclonal antibody labeled with a ruthenium complex(a) reacts

with the C-terminal fragment (38-84). Application of a voltage

to the electrode then induces chemiluminescent emission,

which is measured by a photomultiplier. The antibodies used

in this assay are reactive with epitopes in the amino acid

regions 26-32 and 37-42. (Package insert: Roche PTH reagent,

Roche Diagnostics Corp, Indianapolis, IN November 2006)

Performing Laboratory Location

Rochester

Key