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Test Catalog

Test ID: VMA    
Vanillylmandelic Acid (VMA), 24 Hour, Urine

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Useful For Suggests clinical disorders or settings where the test may be helpful

Screening children for catecholamine-secreting tumors with a 24 hour urine collection when requesting vanillylmandelic acid only


Supporting a diagnosis of neuroblastoma


Monitoring patients with a treated neuroblastoma


Vanillylmandelic acid (VMA) and other catecholamine metabolites such as homovanillic acid (HVA) measurement in urine are used for screening children for catecholamine-secreting tumors such as neuroblastoma and other neural crest tumors and monitoring those who have had treatment for these tumors.


More than 90% of individuals with neuroblastoma have elevated VMA and/or HVA.


VMA is not the analyte of choice for diagnosis of pheochromocytoma, which is better detected by testing for metanephrines.


Treatment with L-dopa can impact test results and should be discontinued 24 hours prior to collection. Bactrim can impact test results and should be noted at time of collection.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Vanillylmandelic Acid, 24 Hr, U

Aliases Lists additional common names for a test, as an aid in searching

Vanillylmandelic Acid
3-Methoxy-4-Hydroxymandelic Acid
4-Hydroxy-3-Methoxymandelic Acid
Neuroblastoma Profile