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Test ID: ADE    
Autoimmune Dysautonomia Evaluation, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Investigating idiopathic dysautonomic symptoms


Directing a focused search for cancer in patients with idiopathic dysautonomia


Investigating autonomic symptoms that appear in the course or wake of cancer therapy, and are not explainable by recurrent cancer or metastasis (detection of autoantibodies in this profile helps differentiate autoimmune dysautonomia from the effects of chemotherapy)

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
PAINTInterpretive CommentsNoYes
ANN1SAnti-Neuronal Nuclear Ab, Type 1NoYes
STRStriational (Striated Muscle) Ab, SYesYes
CCNN-Type Calcium Channel AbNoYes
ARBIACh Receptor (Muscle) Binding AbYesYes
GANGAChR Ganglionic Neuronal Ab, SNoYes
VGKCNeuronal (V-G) K+ Channel Ab, SNoYes
GD65SGAD65 Ab Assay, SYesYes
CCPQP/Q-Type Calcium Channel AbNoYes

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
WBNParaneoplastic Autoantibody WBlot,SNoNo
CRMWSCRMP-5-IgG Western Blot, SNoNo
ARMOACh Receptor (Muscle) Modulating AbNoNo
ABLOTAmphiphysin Western Blot, SNoNo
NMDISNMDA-R Ab IF Titer Assay, SNoNo
AMPISAMPA-R Ab IF Titer Assay, SNoNo
GABISGABA-B-R Ab IF Titer Assay, SNoNo
ANN2SAnti-Neuronal Nuclear Ab, Type 2NoNo
ANN3SAnti-Neuronal Nuclear Ab, Type 3NoNo
PCABPPurkinje Cell Cytoplasmic Ab Type 1NoNo
PCAB2Purkinje Cell Cytoplasmic Ab Type 2NoNo
PCATRPurkinje Cell Cytoplasmic Ab Type TrNoNo
AMPHSAmphiphysin Ab, SNoNo
AGN1SAnti-Glial Nuclear Ab, Type 1NoNo

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

If indirect immunofluorescence assay (IFA) (ANN1S) patterns are indeterminate, then paraneoplastic autoantibody Western blot is performed at an additional charge.

If IFA patterns suggest CRMP-5-IgG, then CRMS and/or CRMP-5-IgG Western blot is performed at an additional charge.

If IFA patterns suggest amphiphysin antibody, then AMPHS and/or amphiphysin Western blot is performed at an additional charge.

If IFA (ANN1S) pattern suggests antineuronal nuclear antibody type 2 or type 3, Purkinje cell cytoplasmic antibody type 1, type 2, or type trace, and/or anti-glial nuclear antibody type 1, then ANN2S, ANN3S, PCABP, PCAB2, PCATR, and/or AGN1S is performed at an additional charge.

If IFA pattern suggests NMO/AQP4-IgG, then NMO/AQP4-IgG CBA is performed at an additional charge.

If IFA pattern suggests NMDA-R, then NMDA-R CBA and/or NMDA-R titer is performed at an additional charge.

If IFA pattern suggests AMPA-R, then AMPA-R CBA and/or AMPA-R titer is performed at an additional charge.

If IFA pattern suggests GABA-B-R, then GABA-B-R CBA and/or GABA-B-R titer is performed at an additional charge.

If acetylcholine (Ach) receptor binding antibody is >0.02, then ACh receptor modulating antibodies and CRMP-5-IgG Western blot are performed at an additional charge.


The following algorithms are available in Special Instructions:

-Autoimmune Dysautonomia Evaluation Testing Algorithm

-Paraneoplastic Evaluation Algorithm

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

CCN, GD65S, ARBI, ARMO, GANG, VGKC, CCPQ: Radioimmunoassay (RIA)

WBN, CRMWS, ABLOT: Western Blot       

ANN1S, ANN2S, ANN3S, PCABP, PCAB2, PCATR, AMPHS, CRMS, AGN1S, AMPIS, NMDIS, GABIS: Indirect Immunofluorescence Assay (IFA)

STR: Enzyme Immunoassay (EIA)

NMOCS, NMDCS, AMPCS, GABCS: Cell-Binding Assay (CBA)

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Autoimmune Dysautonomia Eval, S

Aliases Lists additional common names for a test, as an aid in searching

Acetylcholine Receptor (Muscle AChR) Antibodies
AChR (Acetylcholine Receptor)
ANNA (Antineuronal Nuclear Antibody)
Anti-Enteric Neuronal Antibody
Anti-GAD65 (Anti-Glutamic Acid Decarboxylase)
Anti-Skeletal Muscle Antibodies
Calcium Channel Blockers
Cantoxin (Receptor Antibodies)
Cerebellar Antibodies
Collapsin Response-Mediator Protein-5 Antibody (CRMP-5), Serum
Dorsal Root Ganglion Antibody
Glutamate Decarboxylase Antibodies (GAD65)
Hu Antibody
Isaacs disease
Motor End-Plate Antibody
Motor Nerve Terminal Antibodies
Muscle (Skeletal) Antibodies
Muscle Culture Antibodies
Myoid Antibody
N-Type Calcium Channel Antibody
Neuromuscular hyperexcitability
Neuronal ganglionic acetylcholine receptor antibody
Neuronal Nuclear Antibody Panel
Neuronal Potassium Channel Ab
P/Q Type Calcium Channel Antibody
Paraneoplastic Antibodies
Paraneoplastic Autoantibody Evaluation
Paraneoplastic Neurological Autoimmunity
Potassium Channel Antibodies (specify)
Stiff-man Syndrome
Striational (Striated Muscle) Antibodies
VGCC (Voltage-Gated Calcium Channel) Antibodies
Voltage-Gated Potassium Channel Ab