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Test ID: BAKDM    
BCR/ABL, Tyrosine Kinase Inhibitor Resistance, Kinase Domain Mutation Screen

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluating patients with chronic myeloid leukemia and Philadelphia chromosome positive B-cell acute lymphoblastic leukemia receiving tyrosine kinase inhibitor (TKI), therapy, who are apparently failing treatment

 

This is the preferred initial test to identify the presence of acquired BCR-ABL mutations associated with TKI-resistance.

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

If BCR/ABL fusion type (p210, p190, p185 or p230) are not provided, BADX / BCR/ABL, mRNA Detection, Reverse Transcription-PCR (RT-PCR), Qualitative, Diagnostic Assay will be performed at an additional charge.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Reverse Transcription-Polymerase Chain Reaction (RT-PCR) with Fluorescent-Bead Array Analysis Allele-Specific Primer Extension (ASPE) and Detection by Luminex Bead Array
(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

BCR/ABL Mutation, ASPE

Aliases Lists additional common names for a test, as an aid in searching

E255K
E355G
F317L
F369V
G250E
H396R
M244V
M351T
Q252H
T315I
Y253F
Y253H