Identifying individuals who are at increased risk of adverse drug reactions with drugs that are metabolized by UGT1A1, including irinotecan, atazanavir, nilotinib, pazopanib, and belinostat
This test includes gene sequencing of UGT1A1 and the results are interpreted for the purposes of UGT1A1 drug metabolism. If UGT1A1 gene sequencing is desired for interpretation related to hyperbilirubinemia syndromes including Gilbert syndrome and Crigler-Najjar syndrome, order UGT2 / UDP-Glucuronosyl Transferase 1A1 (UGT1A1), Full Gene Sequencing, Hyperbilirubinemia.
|Test ID||Reporting Name||Available Separately||Always Performed|
|UGT1||UGT1A1 Gene Sequence, Irinotecan||No||Yes|
|UGTSQ||UGT, Full Gene Sequencing||No||Yes|
See UGT1A1 Test-Ordering Algorithm in Special Instructions.
Polymerase Chain Reaction (PCR) Followed by Gene Sequencing
(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)
UGT1A1 Gene Sequence, Irinotecan
Uracil Glucuronyl transferase
Uridine Diphosphate Glucosyltransferase 1