Test ID: CDCOM
Celiac Disease Comprehensive Cascade
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Evaluating patients suspected of having celiac disease, including patients with compatible symptoms, patients with atypical symptoms, and individuals at increased risk (family history, previous diagnosis with associated disease). It should be noted that HLA typing is not required to establish a diagnosis of celiac disease. Consider ordering CDSP/89199 Celiac Disease Serology Cascade if HLA typing is not desired or has been previously performed.
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IGA | Immunoglobulin A (IgA), S | Yes | Yes |
| CELI2 | HLA-DQ Typing | Yes, (Order CELI) | Yes |
| CDCM1 | Celiac Disease Interpretation | No | Yes |
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| EMA | Endomysial Abs, S (IgA) | Yes | No |
| DAGL | Gliadin(Deamidated) Ab, IgA, S | Yes | No |
| TTGG | Tissue Transglutaminase Ab, IgG, S | Yes | No |
| DGGL | Gliadin(Deamidated) Ab, IgG, S | Yes | No |
| TTGA | Tissue Transglutaminase Ab, IgA, S | Yes | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
If IgA is age-specified normal, then tissue transglutaminase (tTG) IgA will be performed at an additional charge.
If tTG IgA is equivocal, then endomysial antibodies IgA and deamidated gliadin antibody IgA will be performed at an additional charge.
If IgA is > or =1.0 mg/dL but lower than age-specified normal, then tTG IgA, tTG IgG, deamidated gliadin IgA, and deamidated gliadin IgG will be performed at an additional charge.
If IgA is below detection (<1.0 mg/dL), then tTG IgG and deamidated gliadin IgG will be performed at an additional charge.
The following algorithms are available in Special Instructions:
-Celiac Disease Comprehensive Cascade
-Celiac Disease Comprehensive Cascade for Patients on a Gluten-Free Diet
-Celiac Disease Diagnostic Testing Algorithm
-Celiac Disease Routine Treatment Monitoring Algorithm
-Celiac Disease Serology Cascade
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
IGA/8157: Nephelometry
CELI2/31928: Polymerase Chain Reaction (PCR)/Sequence-Specific Oligonucleotide Probe (SSO)
TTGA/82587, TTGG/83660, DAGL/89029, DGGL/89030: Enzyme-Linked Immunosorbent Assay (ELISA)
EMA/9360: Indirect Immunofluorescence Assay (IFA)
(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
Antiendomysial Antibody
Antimesothelial Antibody
Celiac Disease
Coeliac Disease
Dermatitis Herpetiformis
EA
EMA
Failure to Thrive
Gamma-Globulins, Quantitative
Gliadin Antibodies IgA
Gliadin Antibodies IgG
Gliadin IgA, Serum
Gliadin IgG, Serum
Gluten-sensitive Enteropathy
HLA Celiac Disease Testing
IgA (Immunoglobulin A)
Immunofluorescence Antibodies
Malabsorption
SOft-CDCOM
Sprue
Tissue Transglutaminase (tTG)
Tissue Transglutaminase Ab IgA
Transglutaminase (tTG)
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