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This test is the preferred test for the confirmation of a diagnosis of aminolevulinic acid dehydratase deficiency porphyria
This test will not detect lead intoxication.
Aminolevulinic acid dehydratase (ALAD) activity can be inhibited in situations including hereditary tyrosinemia type 1, lead intoxication, and exposure to styrene, trichloroethylene, or bromobenzene. These causes should be ruled out when considering a diagnosis of ALAD deficiency porphyria (ADP). This method will not exhibit a decreased ALAD enzyme activity due to lead intoxication.
Due to longer specimen stability, this test is the preferred test for analysis of ALAD.
The following algorithms are available in Special Instructions:
-Porphyria (Acute) Testing Algorithm
-Porphyria (Cutaneous) Testing Algorithm
Enzymatic End point/Spectrofluorometric