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Test Catalog

Test ID: MSIO    
Microsatellite Instability (MSI), Tumor

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluation of tumor tissue to identify patients at high risk for having hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome


Note: Mayo's preferred screening test (HNPCC / Hereditary Nonpolyposis Colorectal Cancer [HNPCC] Screen) includes both microsatellite instability (MSI) and Immunohistochemistry (IHC) testing.


Evaluation of tumor tissue for clinical decision making purposes given the prognostic implications associated with MSI phenotypes

Genetics Test Information Provides information that may help with selection of the correct test or proper submission of the test request

Only microsatellite instability (MSI) testing is performed.

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
TUMSIMicrosatellite Instability, TumorNoYes

Additional Tests Lists test(s) that are always performed, at an additional charge, with the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
SLRVWSlide ReviewNoYes

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

When this test is ordered, slide review for molecular genetics will always be performed at an additional charge.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

A Polymerase Chain Reaction (PCR)-based assay is used to test for tumor microsatellite instability with the use of 5 mononucleotide repeats.

(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Microsatellite Instability, Tumor

Aliases Lists additional common names for a test, as an aid in searching

DNA Mismatch Repair-related HNPCC
Hereditary Nonpolyposis Colon Cancer (HNPCC)
Lynch Syndrome
Microsatellite Instability (MSI)
Tumor Microsatellite Instability (MSI)