|Values are valid only on day of printing.|
Screening for common variable immunodeficiency (CVID)
Identifying defects in TACI and BAFF-R in patients presenting with clinical symptoms and other laboratory features consistent with CVID
Evaluating B cell immune competence by assessing expression of BAFF-R and TACI proteins
Useful for assessing BAFF-R and TACI protein expression and frequency of B cells bearing these receptors. TNFRSF13C (BAFF-R) and TNFRSF13B (TACI) gene mutations have been described in a small subset of patients with humoral immunodeficiencies classified as CVID. The majority of TNFRSF13B mutations preserve TACI protein expression and require genetic testing to identify pathogenic or potentially pathogenic mutations/variants.
Fluorescent Flow Cytometry