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Test ID: BRAF    
BRAF Mutation Analysis (V600E), Tumor

Secondary ID A test code used for billing and in test definitions created prior to November 2011

87980

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Useful For Suggests clinical disorders or settings where the test may be helpful

As an adjunct to HNPCC / Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Screen, when colon tumor demonstrates microsatellite instability (MSI-H) and loss of MLH1 protein expression, to help distinguish a somatic versus germline event prior to performing expensive germline testing

 

As an adjunct to negative MLH1 germline testing in cases where colon tumor demonstrates MSI-H and loss of MLH1 protein expression

 

Note: Mayo's preferred screening test (MLBRF / MLH1 Hypermethylation and BRAF Mutation Analyses) includes both MLH1 promoter hypermethylation and BRAF V600E testing.

 

To identify colon tumors with a previously negative KRAS mutation analysis result that may respond to epidermal growth factor receptor-targeted therapies.

 

To identify melanoma tumors that may respond to anti-BRAF targeted therapies. Note, this is a laboratory developed test and has not been FDA-approved for this purpose.  

Additional Tests Lists test(s) that are always performed, at an additional charge, with the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
SLRVWSlide ReviewNoYes

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

When this test is ordered, slide review will always be performed at an additional charge.

 

See Hereditary Nonpolyposis Colorectal Cancer Testing Algorithm in Special Instructions.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR) Analysis

(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

BRAF Mutation Analysis(V600E),Tumor

Aliases Lists additional common names for a test, as an aid in searching

V600E