Test ID: MLBRF
MLH1 Hypermethylation and BRAF Mutation Analyses, Tumor
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
Useful For Suggests clinical disorders or settings where the test may be helpful
As an adjunct to HNPCC/17073 Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Screen, when colon tumor demonstrates microsatellite instability (MSI-H) and loss of MLH1 protein expression, to help distinguish a somatic versus germline event prior to performing expensive germline testing
As an adjunct to negative MLH1 germline testing in cases where colon tumor from the same patient demonstrates MSI-H and loss of MLH1 protein expression
Genetics Test Information Provides information that may help with selection of the correct test or proper submission of the test request
If this test is ordered in conjunction with the HNPCC screen (HNPCC/17073) or MLH1 immunostain (IHCO/29004) and MSI (MSIO/88566), this test (MLBRF/87931) will only be performed when clinically indicated.
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| MLHHM | MLH1 Hypermethylation | Yes, (order 87978) | Yes |
| BRAFP | BRAF Mutation Analysis (V600E) | Yes, (order 87980) | Yes |
| MBPIN | MLH1 Hyp/BRAF (V600E) Mut Interp | No | Yes |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
See Hereditary Nonpolyposis Colorectal Cancer Testing Algorithm in Special Instructions.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
Polymerase Chain Reaction (PCR) Analysis
(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
BRAF V600E
Hypermethylation
MLH1 Hypermethylation
Promoter Hypermethylation
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