Test ID: FAML
Acute Myeloid Leukemia (AML), FISH
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
Useful For Suggests clinical disorders or settings where the test may be helpful
Detecting a neoplastic clone associated with the common chromosome anomalies seen in patients with acute myeloid leukemia or other myeloid malignancies
Evaluating specimens in which standard cytogenetic analysis is unsuccessful
Identifying known chromosome anomalies in patients with myeloid malignancies and tracking response to therapy
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Secondary ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|---|
| ADD1F | 80024 | One Additional FISH Probe | No | No |
| ADD2F | 80025 | Two Additional FISH Probes | No | No |
| ADD4F | 80026 | Four Additional FISH Probes | No | No |
| ADD3F | 87825 | Three Additional FISH Probes | No | No |
| ADD5F | 87826 | Five Additional FISH Probes | No | No |
| ADD6F | 87827 | Six Additional FISH Probes | No | No |
| ADD7F | 87828 | Seven Additional FISH Probes | No | No |
| ADD8F | 87829 | Eight Additional FISH Probes | No | No |
| ADD9F | 87830 | Nine Additional FISH Probes | No | No |
| ADD10 | 87831 | Ten Additional FISH Probes | No | No |
| ADD11 | 87832 | Eleven Additional FISH Probes | No | No |
| ADD12 | 87833 | Twelve Additional FISH Probes | No | No |
| 14FP | 89714 | Fourteen Additional FISH Probes | No | No |
| 13FP | 89741 | Thirteen Additional FISH Probes | No | No |
| 15FP | 89715 | Fifteen Additional FISH Probes | No | No |
| 16FP | 89716 | Sixteen Additional FISH Probes | No | No |
| 17FP | 89717 | Seventeen Additional FISH Probes | No | No |
| 18FP | 89718 | Eighteen Additional FISH Probes | No | No |
| 19FP | 89719 | Nineteen Additional FISH Probes | No | No |
| 20FP | 89720 | Twenty Additional FISH Probes | No | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
Indicate subtype as well as which anomalies need to be investigated from the following profile:
t(8:21), [M2], RUNX1T1/RUNX1
t(15:17), [M3], PML/RARA
t(11q23:var), [M0-M7], MLL
inv(16), [M4, Eos], MYH11/CBFb
+8, [M0-M7], Cen8/MYC
t(6;9), [M2,M4], DEK/CAN
inv(3), [M1,2,4,6,7], RPN1/MECOM
t(8;16), [M4,M5], MYST3/CREBBP
-5/5q-, D5S630/EGR1
-7/7q-, D7S486/Cen7
13q-, D13S319/LAMP1
20q-, D20S108/20qter
t(9;22), BCR/ABL
If the patient is being treated for known anomalies, indicate which anomalies need to be investigated.
When an MLL rearrangement is identified, reflex testing is performed to identify the translocation partner. Probes include identification of t(6;11)(q27;q23) AF6/MLL, t(9;11)(p22;q23) AF9/MLL, t(10;11)(p13;q23) AF10/MLL, t(11;19)(q23;p13.1) MLL/ELL. When a MECOM rearrangement is observed, reflex testing is performed to identify a potential t(3;21)(q26.2;q22) MECOM/RUNX1.
When this test is ordered, a charge for 2 FISH probes and interpretation is included. If additional probes or the entire panel are ordered, additional probe charges will be added.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
Fluorescence In Situ Hybridization (FISH)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
-7
11q23
5q-
7q-
Acute Myeloid Leukemia (AML)
Acute Promyelocytic Leukemia (APL)
AF6/MLL
AF9/MLL
AML-M2
AML-M3
AML-M4
AML-M4eo
AML-M5
APL (Acute Promyelocytic Leukemia)
DEK/CAN
Deletion 5q
Deletion 7q
ETO/AML1
EVI1/AML1
FISH (Fluorescence In Situ Hybridization)
Inv(16)
Inv(3)
inversion 16
inversion 3
MLL
MYH11/CBFb
MYST3/CREBBP
NUP214
PML/RARA
t(15:17)
t(16:16)
t(3:21)
t(3;3)
t(6;9)
t(8:16)
t(8;21)
t(9;11)
RUNX1T1/RUNX1
MECOM/RUNX1
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