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Test ID: FAML
Acute Myeloid Leukemia (AML), FISH

Secondary ID A test code used for billing and in test definitions created prior to November 2011

87894

Useful For Suggests clinical disorders or settings where the test may be helpful

Detecting a neoplastic clone associated with the common chromosome anomalies seen in patients with acute myeloid leukemia or other myeloid malignancies

 

Evaluating specimens in which standard cytogenetic analysis is unsuccessful

 

Identifying known chromosome anomalies in patients with myeloid malignancies and tracking response to therapy

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDSecondary IDReporting NameAvailable SeparatelyAlways Performed
ADD1F80024One Additional FISH ProbeNoNo
ADD2F80025Two Additional FISH ProbesNoNo
ADD4F80026Four Additional FISH ProbesNoNo
ADD3F87825Three Additional FISH ProbesNoNo
ADD5F87826Five Additional FISH ProbesNoNo
ADD6F87827Six Additional FISH ProbesNoNo
ADD7F87828Seven Additional FISH ProbesNoNo
ADD8F87829Eight Additional FISH ProbesNoNo
ADD9F87830Nine Additional FISH ProbesNoNo
ADD1087831Ten Additional FISH ProbesNoNo
ADD1187832Eleven Additional FISH ProbesNoNo
ADD1287833Twelve Additional FISH ProbesNoNo
14FP89714Fourteen Additional FISH ProbesNoNo
13FP89741Thirteen Additional FISH ProbesNoNo
15FP89715Fifteen Additional FISH ProbesNoNo
16FP89716Sixteen Additional FISH ProbesNoNo
17FP89717Seventeen Additional FISH ProbesNoNo
18FP89718Eighteen Additional FISH ProbesNoNo
19FP89719Nineteen Additional FISH ProbesNoNo
20FP89720Twenty Additional FISH ProbesNoNo

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

Indicate subtype as well as which anomalies need to be investigated from the following profile:

 

t(8:21), [M2], RUNX1T1/RUNX1

t(15:17), [M3], PML/RARA

t(11q23:var), [M0-M7], MLL

inv(16), [M4, Eos], MYH11/CBFb

+8, [M0-M7], Cen8/MYC

t(6;9), [M2,M4], DEK/CAN

inv(3), [M1,2,4,6,7], RPN1/MECOM

t(8;16), [M4,M5], MYST3/CREBBP

-5/5q-, D5S630/EGR1

-7/7q-, D7S486/Cen7

13q-, D13S319/LAMP1

20q-, D20S108/20qter

t(9;22), BCR/ABL

 

If the patient is being treated for known anomalies, indicate which anomalies need to be investigated.

 

When an MLL rearrangement is identified, reflex testing is performed to identify the translocation partner. Probes include identification of t(6;11)(q27;q23) AF6/MLL, t(9;11)(p22;q23) AF9/MLL, t(10;11)(p13;q23) AF10/MLL, t(11;19)(q23;p13.1) MLL/ELL. When a MECOM rearrangement is observed, reflex testing is performed to identify a potential t(3;21)(q26.2;q22) MECOM/RUNX1.

 

When this test is ordered, a charge for 2 FISH probes and interpretation is included. If additional probes or the entire panel are ordered, additional probe charges will be added.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Fluorescence In Situ Hybridization (FISH)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

AML, FISH

Aliases Lists additional common names for a test, as an aid in searching

-5
-7
11q23
5q-
7q-
Acute Myeloid Leukemia (AML)
Acute Promyelocytic Leukemia (APL)
AF6/MLL
AF9/MLL
AML-M2
AML-M3
AML-M4
AML-M4eo
AML-M5
APL (Acute Promyelocytic Leukemia)
DEK/CAN
Deletion 5q
Deletion 7q
ETO/AML1
EVI1/AML1
FISH (Fluorescence In Situ Hybridization)
Inv(16)
Inv(3)
inversion 16
inversion 3
MLL
MYH11/CBFb
MYST3/CREBBP
NUP214
PML/RARA
t(15:17)
t(16:16)
t(3:21)
t(3;3)
t(6;9)
t(8:16)
t(8;21)
t(9;11)
RUNX1T1/RUNX1
MECOM/RUNX1