|Values are valid only on day of printing.|
Distinguishing between primary and secondary hyperoxaluria
Distinguishing between primary hyperoxaluria types 1, 2, and 3
Distinguishing among primary hyperoxaluria types 1, 2, and 3, and secondary hyperoxaluria.
Primary hyperoxalurias (PH), classified into types 1, 2, and 3, are genetic disorders of oxalate metabolism characterized by increased urinary excretion of oxalic acid and kidney stone formation.
Secondary hyperoxaluria is an acquired condition resulting from either increased intake of dietary oxalate or altered intestinal oxalate absorption.
A diagnostic workup in an individual with hyperoxaluria demonstrates increased concentration of oxalate in urinary metabolite screening. If glycolate, glycerate, or 4-hydroxy-2-oxoglutarate is present, a primary hyperoxaluria is indicated.
Each type is distinguished from the others based on the urine profile.
Ascorbic acid will falsely elevate oxalic acid results.
See Hyperoxaluria Diagnostic Algorithm in Special Instructions.
Gas Chromatography-Mass Spectrometry (GC-MS)