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Distinguishing between primary and secondary hyperoxaluria
Distinguishing between type 1 and type 2 primary hyperoxaluria
Distinguishing between primary and secondary hyperoxaluria.
Primary hyperoxalurias are genetic disorders of glyoxylate metabolism characterized by increased urinary excretion of oxalic acid and kidney stone formation.
A diagnostic workup in an individual with hyperoxaluria demonstrates increased concentration of oxalate in urinary metabolite screening. If glycolate or glycerate is present, a primary hyperoxaluria is indicated.
Primary hyperoxalurias are distinguished from each other based on the urine profile.
Ascorbic acid will falsely elevate oxalic acid results.
See Hyperoxaluria Diagnostic Algorithm in Special Instructions.
Gas Chromatography-Mass Spectrometry (GC-MS)