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Test ID: FMDS    
Myelodysplastic Syndrome (MDS), FISH

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Conditional

Useful For Suggests clinical disorders or settings where the test may be helpful

Detecting a neoplastic clone associated with the common chromosome anomalies seen in patients with myelodysplastic syndromes or other myeloid malignancies

 

Evaluating specimens in which standard cytogenetic analysis is unsuccessful

 

Identifying and tracking known chromosome anomalies in patients with myeloid malignancies and tracking response to therapy

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
ADD1FOne Additional FISH ProbeNoNo
ADD2FTwo Additional FISH ProbesNoNo
ADD3FThree Additional FISH ProbesNoNo
ADD4FFour Additional FISH ProbesNoNo
ADD5FFive Additional FISH ProbesNoNo
ADD6FSix Additional FISH ProbesNoNo
ADD7FSeven Additional FISH ProbesNoNo
ADD8FEight Additional FISH ProbesNoNo
ADD9FNine Additional FISH ProbesNoNo
ADD10Ten Additional FISH ProbesNoNo
ADD11Eleven Additional FISH ProbesNoNo
ADD12Twelve Additional FISH ProbesNoNo
14FPFourteen Additional FISH ProbesNoNo
13FPThirteen Additional FISH ProbesNoNo
15FPFifteen Additional FISH ProbesNoNo
16FPSixteen Additional FISH ProbesNoNo
17FPSeventeen Additional FISH ProbesNoNo
18FPEighteen Additional FISH ProbesNoNo
19FPNineteen Additional FISH ProbesNoNo
20FPTwenty Additional FISH ProbesNoNo
21FPTwenty One Additional FISH ProbesNoNo
22FPTwenty Two Additional FISH ProbesNoNo
23FPTwenty Three Additional FISH ProbesNoNo
24FPTwenty Four Additional FISH ProbesNoNo
25FPTwenty Five Additional FISH ProbesNoNo
26FPTwenty Six Additional FISH ProbesNoNo
27FPTwenty Seven Additional FISH ProbesNoNo
28FPTwenty Eight Additional FISH ProbesNoNo
29FPTwenty Nine Additional FISH ProbesNoNo
30FPThirty Additional FISH ProbesNoNo

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

Chromosome analysis is recommended as first-tier testing for this disorder; FISH should be used if chromosomes are not successful.

 

When this test is ordered, a charge for 2 FISH probes and interpretation is included. If additional probes or the entire panel are ordered, additional probe charges will be added.

 

Please indicate if the entire panel is to be performed. This is suggested for newly diagnosed patients. If the patient is being tracked for known anomalies, indicate which anomalies need to be investigated.

 

Panel includes testing for the following anomalies via the probes listed:

-5/5q-, D5S630/EGR1

-7/7q-, D7S486/Cen7

+8, Cen8/MYC

11q23 rearrangements, MLL

13q-, D13S319/LAMP1

17p-, TP53/cen17

20q-, D20S108/20qter

inv(3)/3q21 or 3q26.2 rearrangements, RPN1/MECOM

 

-When an MLL rearrangement is identified, reflex testing is performed to identify the translocation partner. Probes include identification of t(6;11)(q27;q23) MLTT4/MLL, t(9;11)(p22;q23) MLLT3/MLL, t(11;16)(q23;p13.3) MLL/CREBBP,  t(11;19)(q23;p13.1) MLL/ELL, or t(11;19)(q23;p13.3) MLL/MLLT1.

-When 3 copies of MECOM are observed with no fusion with RPN1, reflex testing using the MECOM/RUNX1 probe set is performed to identify a potential t(3;21)(q26.2;q22) rearrangement.

-When 3 copies of RPN1 are observed with no fusion with MECOM, reflex testing using the PRDM16/RPN1 probe set is performed to identify a potential t(1;3)(p36;q21).

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Fluorescence In Situ Hybridization (FISH)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

MDS, FISH

Aliases Lists additional common names for a test, as an aid in searching

+8
-5
-7
11q23
13q-
20q-
5q-
7q-
AF6/MLL
AF9/MLL
Deletion 13q
Deletion 20q
Deletion 5q
Deletion 7q
FISH (Fluorescence In Situ Hybridization)
MDS (Myelodysplastic Syndrome)
MLL/ELL+8
Monosomy 5
Monosomy 7
t(11:19)
t(3:21)
t(3;3)
t(6:11)
t(9:11)
Trisomy 8
RPN1/EVI1
RPN1/MECOM
EVI1/AML1
Isodicentric 20q
MLL/ENL
MLL/MLLT1
MLLT4/MLL
MLLT3/MLL
PRDM16/RPN1
RPN1/AML1
t(1;3)
17p-
Deletion 17p
idic(20)
inv(3)
inversion 3
MECOM/RUNX1
MLL/CREBBP
Myeloproliferative neoplasms
Myelodysplastic Syndrome
MPN
t(11;16)
TP53