Test ID: FMDS
Myelodysplastic Syndrome (MDS), FISH
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
Useful For Suggests clinical disorders or settings where the test may be helpful
Detecting a neoplastic clone associated with the common chromosome anomalies seen in patients with myelodysplastic syndromes or other myeloid malignancies
Evaluating specimens in which standard cytogenetic analysis is unsuccessful
Identifying and tracking known chromosome anomalies in patients with myeloid malignancies
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Secondary ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|---|
| ADD6F | 87827 | Six Additional FISH Probes | No | No |
| 13FP | 89741 | Thirteen Additional FISH Probes | No | No |
| 14FP | 89714 | Fourteen Additional FISH Probes | No | No |
| 15FP | 89715 | Fifteen Additional FISH Probes | No | No |
| 16FP | 89716 | Sixteen Additional FISH Probes | No | No |
| 17FP | 89717 | Seventeen Additional FISH Probes | No | No |
| 18FP | 89718 | Eighteen Additional FISH Probes | No | No |
| 19FP | 89719 | Nineteen Additional FISH Probes | No | No |
| 20FP | 89720 | Twenty Additional FISH Probes | No | No |
| ADD10 | 87831 | Ten Additional FISH Probes | No | No |
| ADD11 | 87832 | Eleven Additional FISH Probes | No | No |
| ADD12 | 87833 | Twelve Additional FISH Probes | No | No |
| ADD1F | 80024 | One Additional FISH Probe | No | No |
| ADD2F | 80025 | Two Additional FISH Probes | No | No |
| ADD3F | 87825 | Three Additional FISH Probes | No | No |
| ADD4F | 80026 | Four Additional FISH Probes | No | No |
| ADD5F | 87826 | Five Additional FISH Probes | No | No |
| ADD7F | 87828 | Seven Additional FISH Probes | No | No |
| ADD8F | 87829 | Eight Additional FISH Probes | No | No |
| ADD9F | 87830 | Nine Additional FISH Probes | No | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
Chromosome analysis is recommended as first tier testing for this disorder; FISH should be used if chromosomes are not successful. Panel includes testing for the following anomalies via the probes listed:
-5/5q-, D5S630/EGR1
-7/7q-, D7S486/Cen7
+8, Cen8/MYC
11q23 rearrangements, MLL
13q-, D13S319/LAMP1
20q-, D20S108/20qter
inv(3)/3q21or 3q26.2 rearrangements, RPN1/EVI1(MECOM)
Please indicate if you would like us to run the entire panel. This is suggested for patients with a new diagnosis. If the patient is being tracked for known anomalies, please indicate which anomalies need to be investigated.
Reflex Testing:
When an MLL rearrangement is identified, reflex testing is performed to identify the translocation partner. Probes include identification of t(6;11)(q27;q23) AF6(MLTT4)/MLL, t(9;11)(p22;q23) AF9(MLLT3)/MLL, t(10;11)(p13;q23) AF10/MLL, t(11;19)(q23;p13.1) MLL/ELL, or t(11;19)(q23;p13.3) MLL/ENL(MLLT1).
When 3 copies of EVI1 (MECOM) are observed, reflex testing using the EVI1(MECOM)/AML1.(RUNX1) probe set is performed to identify a potential t(3;21)(q26.2;q22) rearrangement.
When 3 copies of RPN1 are observed, reflex testing using the PRDM16/RPN1 probe set is performed to identify a potential t(1;3)(p36;q21) rearrangement.
When this test is ordered, a charge for 2 FISH probes and interpretation is included. If additional probes or the entire panel are ordered, additional probe charges will be added.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
Fluorescence In Situ Hybridization (FISH)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
-5
-7
11q23
13q-
20q-
5q-
7q-
AF10/MLL
AF6/MLL
AF9/MLL
Deletion 13q
Deletion 20q
Deletion 5q
Deletion 7q
FISH (Fluorescence In Situ Hybridization)
Inv(3)
Inversion 3
MDS (Myelodysplastic Syndrome)
MLL/ELL+8
Monosomy 5
Monosomy 7
Myelodysplastic Syndrome (MDS)
t(10:11)
t(11:19)
t(3:21)
t(3;3)
t(6:11)
t(9:11)
Trisomy 8
RPN1/EVI1
RPN1/MECOM
EVI1/AML1
Idic(20)
Isodicentric 20q
MLL/ENL
MLL/MLLT1
MLLT4/MLL
MLLT3/MLL
PRDM16/RPN1
RPN1/AML1
RPN1/RUNX1
t(1;3)
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